| Initial cytomegalovirus prophylaxis with ganciclovir: no guarantee for prevention of late serious manifestations of CMV after solid organ transplantation. | |
| | |
MedLine Citation:
|
PMID: 16301763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 37-year-old woman presented with malaise, upper abdominal pain and fever seven months after renal transplantation. She was seronegative for cytomegalovirus (CMV) and had received a kidney from a seropositive donor. She had received CMV prophylaxis (oral ganciclovir) for three months after transplantation. During this period all tests for CMV remained negative. On admission, she presented with symptoms compatible with an acute abdomen and with deterioration of renal function. On emergency laparotomy a perforation of the ileum was found. The resected specimen showed an ulcer with vasculitis at the site of perforation, with both microscopic (owl's eye inclusion bodies), as well as immunohistochemical evidence for a CMV infection. CMV can reactivate (usually in the first three months) after transplantation, sometimes resulting in serious morbidity. The use of antiviral prophylaxis during and after transplantation has certainly decreased the number and severity of CMV infections. This case illustrates that life-threatening infections such as CMV can still emerge a long time after transplantation. Unrelenting awareness of this condition is mandatory, even after apparently adequate anti-CMV prophylaxis. |
| | |
Authors:
|
M Zandberg; E F de Maar; H S Hofker; J J Homan van der Heide; S Rosati; W J van Son |
Related Documents
:
|
17625763 - The incidence of cytomegalovirus infection in lung transplant recipients under universa... 9028553 - Increased incidence of cytomegalovirus (cmv) infection and cmv-associated disease after... 12630943 - Ocular tissue interactions during the development of human fetal neuroretina grafted in... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Netherlands journal of medicine Volume: 63 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-11-22 Completed Date: 2005-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 408-12 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Division of Nephrology, Groningen University Medical Centre, Groningen, the Netherlands. marietzandberg@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antiviral Agents / therapeutic use* Cytomegalovirus / physiology Cytomegalovirus Infections / etiology*, prevention & control Female Ganciclovir / therapeutic use* Humans Kidney Transplantation / adverse effects* Time Factors Virus Activation |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 82410-32-0/Ganciclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term blood pressure monitoring and echocardiographic findings in patients with end-stage renal ...
Next Document: Psoas abscess: report of a series and review of the literature.