| Initial combination therapy compared with monotherapy in diabetic hypertensive patients. | |
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MedLine Citation:
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PMID: 18844761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subgroup analyses were performed for the diabetic and nondiabetic cohorts from 3 randomized clinical trials that had evaluated the systolic blood pressure (SBP)-lowering efficacy and tolerability of an angiotensin receptor blocker, valsartan, alone or in combination with hydrochlorothiazide to determine when and how to initiate combination therapy in hypertensive patients with diabetes. Blood pressure reductions achieved with monotherapy were compared with combination therapy in the diabetic and nondiabetic cohorts. In addition, multivariate models were developed to predict the likelihood of the goal SBP of < 130 mm Hg being reached in a diabetic patient with monotherapy or combination therapy across the range of baseline SBP values. In 2 of the 3 trials, comparable reductions in SBP were seen in the diabetic and nondiabetic cohorts. In all 3 studies, however, combination therapy provided greater blood pressure-lowering efficacy than monotherapy. The probability of achieving goal SBP was greater for diabetic patients started on combination therapy compared with monotherapy. |
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Authors:
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James R Sowers; Guido Lastra; Ricardo Rocha; Yodit Seifu; Nora Crikelair; Drew G Levy |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 10 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-10 Completed Date: 2009-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 668-76 Citation Subset: IM |
Affiliation:
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Diabetes and Cardiovascular Center, University of Missouri School of Medicine, Columbia, MO, USA. sowersj@health.missouri.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Antihypertensive Agents / administration & dosage, therapeutic use* Blood Glucose / metabolism Blood Pressure / physiology C-Reactive Protein / metabolism Diabetes Mellitus, Type 1 / blood, complications*, drug therapy Diabetes Mellitus, Type 2 / blood, complications*, drug therapy Diuretics / administration & dosage, therapeutic use* Dose-Response Relationship, Drug Double-Blind Method Drug Therapy, Combination Female Follow-Up Studies Humans Hydrochlorothiazide / administration & dosage, therapeutic use* Hypertension / complications, drug therapy*, physiopathology Hypoglycemic Agents / therapeutic use Male Middle Aged Severity of Illness Index Tetrazoles / administration & dosage, therapeutic use* Treatment Outcome Valine / administration & dosage, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Diuretics; 0/Hypoglycemic Agents; 0/Tetrazoles; 137862-53-4/valsartan; 58-93-5/Hydrochlorothiazide; 7004-03-7/Valine; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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