| Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. | |
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MedLine Citation:
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PMID: 19303334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current models of the germinal center (GC) response propose that after stimulation at the edges of T cell zones, pre-GC B cells directly migrate to the center of follicles and proliferate to form GCs. We followed the interrelationship of proliferation, differentiation, and microenvironmental locale in populations of pre-GC B cells responding to antigen. In contrast to the predictions of current models, after accumulation at the T-B interface, these cells appeared at the perimeter of follicles adjacent to the marginal zone. There, they rapidly proliferated for several days but underwent no V gene hypermutation and little heavy-chain class switching. Their chemokine receptor expression pattern indicated that these cells were sessile, yet they had begun to acquire many phenotypic characteristics of GC B cells. The expanded clones were subsequently observed in the center of follicles, suggesting that GCs are created by coalescence of B cells from this follicular perimeter response. |
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Authors:
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Francis Coffey; Boris Alabyev; Tim Manser |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-19 |
Journal Detail:
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Title: Immunity Volume: 30 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-17 Completed Date: 2009-05-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 599-609 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / cytology, immunology* Cell Proliferation Cells, Cultured Dendritic Cells, Follicular / immunology* Flow Cytometry Fluorescent Antibody Technique Gene Expression Profiling Germinal Center / cytology*, immunology* Mice Mice, Transgenic |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI038965-12/AI/NIAID NIH HHS; R01 AI046806-10/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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