Document Detail


Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles.
MedLine Citation:
PMID:  19303334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current models of the germinal center (GC) response propose that after stimulation at the edges of T cell zones, pre-GC B cells directly migrate to the center of follicles and proliferate to form GCs. We followed the interrelationship of proliferation, differentiation, and microenvironmental locale in populations of pre-GC B cells responding to antigen. In contrast to the predictions of current models, after accumulation at the T-B interface, these cells appeared at the perimeter of follicles adjacent to the marginal zone. There, they rapidly proliferated for several days but underwent no V gene hypermutation and little heavy-chain class switching. Their chemokine receptor expression pattern indicated that these cells were sessile, yet they had begun to acquire many phenotypic characteristics of GC B cells. The expanded clones were subsequently observed in the center of follicles, suggesting that GCs are created by coalescence of B cells from this follicular perimeter response.
Authors:
Francis Coffey; Boris Alabyev; Tim Manser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-19
Journal Detail:
Title:  Immunity     Volume:  30     ISSN:  1097-4180     ISO Abbreviation:  Immunity     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-14     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  599-609     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / cytology,  immunology*
Cell Proliferation
Cells, Cultured
Dendritic Cells, Follicular / immunology*
Flow Cytometry
Fluorescent Antibody Technique
Gene Expression Profiling
Germinal Center / cytology*,  immunology*
Mice
Mice, Transgenic
Grant Support
ID/Acronym/Agency:
R01 AI038965/AI/NIAID NIH HHS; R01 AI038965-12/AI/NIAID NIH HHS; R01 AI046806/AI/NIAID NIH HHS; R01 AI046806-10/AI/NIAID NIH HHS
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