| Initial characterization of hamsters with spontaneous hypertension. | |
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MedLine Citation:
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PMID: 9260996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to begin to characterize a new inbred strain of adult male hamsters with established spontaneous hypertension along with their genetically/age-matched normotensive controls. We found that mean arterial pressure was 162+/-3 mm Hg in hypertensive hamsters and 94+/-4 mm Hg in controls (mean+/-SEM; P<.05). Body weight was significantly lower in hypertensive hamsters relative to normotensive hamsters (P<.05). Hypertension was associated with a significant increase in heart weight, thickness of the left ventricular wall, and amplitude of the QRS complex in standard electrocardiographic leads I and aVR (P<.05). No gross or microscopic abnormalities were observed in other organs. Plasma renin activity and the number of circulating neutrophils were significantly increased in hypertensive hamsters relative to controls (P<.05). Serum concentrations of creatinine, blood urea nitrogen, sodium, potassium, and calcium as well as urinalysis were similar in both groups. Overall, these data suggest that the spontaneously hypertensive hamster could be a suitable model for the study of spontaneous hypertension. |
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Authors:
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C L Thomas; J E Artwohl; H Suzuki; X Gao; E White; A Saroli; R M Bunte; I Rubinstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 30 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-11 Completed Date: 1997-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 301-4 Citation Subset: IM |
Affiliation:
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Biologic Resources Laboratory, University of Illinois at Chicago, 60612-7323, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cell Count Blood Pressure Body Weight Cricetinae* Disease Models, Animal* Electrocardiography Hypertension / pathology, physiopathology, veterinary* Male Myocardium / pathology Organ Size Rodent Diseases / blood, pathology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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DE00386/DE/NIDCR NIH HHS; DE10347/DE/NIDCR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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