Document Detail


Initial characterization of hamsters with spontaneous hypertension.
MedLine Citation:
PMID:  9260996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to begin to characterize a new inbred strain of adult male hamsters with established spontaneous hypertension along with their genetically/age-matched normotensive controls. We found that mean arterial pressure was 162+/-3 mm Hg in hypertensive hamsters and 94+/-4 mm Hg in controls (mean+/-SEM; P<.05). Body weight was significantly lower in hypertensive hamsters relative to normotensive hamsters (P<.05). Hypertension was associated with a significant increase in heart weight, thickness of the left ventricular wall, and amplitude of the QRS complex in standard electrocardiographic leads I and aVR (P<.05). No gross or microscopic abnormalities were observed in other organs. Plasma renin activity and the number of circulating neutrophils were significantly increased in hypertensive hamsters relative to controls (P<.05). Serum concentrations of creatinine, blood urea nitrogen, sodium, potassium, and calcium as well as urinalysis were similar in both groups. Overall, these data suggest that the spontaneously hypertensive hamster could be a suitable model for the study of spontaneous hypertension.
Authors:
C L Thomas; J E Artwohl; H Suzuki; X Gao; E White; A Saroli; R M Bunte; I Rubinstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  30     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
Affiliation:
Biologic Resources Laboratory, University of Illinois at Chicago, 60612-7323, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Cell Count
Blood Pressure
Body Weight
Cricetinae*
Disease Models, Animal*
Electrocardiography
Hypertension / pathology,  physiopathology,  veterinary*
Male
Myocardium / pathology
Organ Size
Rodent Diseases / blood,  pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
DE00386/DE/NIDCR NIH HHS; DE10347/DE/NIDCR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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