Document Detail

Initial results of inflammatory response, matrix remodeling, and reactive oxygen species following PCI in acute ischemic myocardial injury in man.
MedLine Citation:
PMID:  21891809     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neutrophils and reactive oxygen species (ROS) are suggested to be involved in irreversible myocardial reperfusion injury and stunning. We investigated the relations between circulating biochemical markers and myocardium at risk (MaR), myocardial infarct (MI) size, salvage, and recovery of function in man.
METHODS AND RESULTS: In patients undergoing PCI serial blood samples were acquired for markers of inflammatory response (myeloperoxidase [MPO], neutrophil-gelatinase-associated lipocalin [NGAL], interleukins 6 and 8 [IL-6/8], tumor necrosis factor-a [TNF-a], high-sensitive C-reactive protein [hsCRP]), matrix remodeling (matrixmetalloproteinase-9 [MMP-9]) and ROS (malondialdehyde [MDA], isoprostane [IsoP]). Samples were obtained before PCI and 1.5, 3, and 24 hours after reperfusion. Myocardial perfusion SPECT (MPS) was used to assess MaR. Late gadolinum-enhanced cardiac magnetic resonance imaging was performed for regional function in the acute setting, at 1 week and 6 months, and at 1 week also for MI size. Sixteen patients (15 men; 42-78 years) were enrolled, 12 of whom underwent MPS. Peak and cumulative NGAL and cumulative MMP-9 showed inverse correlations to MaR. No correlation was found for MI size. Peak MPO correlated inversely to salvage and to recovery of regional function in the infarcted segments at 1 week and 6 months.
CONCLUSIONS: This is the first study in man to show inverse relations between circulating NGAL and MMP-9 and MaR. The current results do not support that ROS has a role in stunning in man. MI size showed no significant correlation to any parameter, challenging inflammatory treatment in reperfusion.
Erik Hedström; Karin Aström-Olsson; Ann-Kristin Ohlin; Hans Ohlin; Håkan Arheden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  23     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-05     Completed Date:  2012-01-11     Revised Date:  2013-09-24    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Department of Clinical Physiology, Lund, Sweden.
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MeSH Terms
Acute Disease
Angioplasty, Balloon, Coronary / adverse effects*
Biological Markers
C-Reactive Protein
Inflammation / etiology,  pathology
Magnetic Resonance Imaging, Cine
Matrix Metalloproteinase 9 / immunology*
Middle Aged
Myocardial Infarction / therapy*
Myocardial Ischemia / etiology*,  pathology
Myocardial Reperfusion / adverse effects
Reactive Oxygen Species*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Biological Markers; 0/Reactive Oxygen Species; 9007-41-4/C-Reactive Protein; EC Metalloproteinase 9

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