Document Detail

Initial lesion volume is an independent predictor of clinical stroke outcome at day 90: an analysis of the Virtual International Stroke Trials Archive (VISTA) database.
MedLine Citation:
PMID:  22403046     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Age and National Institutes of Health Stroke Scale early after stroke onset have been identified as important determinants of final stroke outcome. We analyzed the Virtual International Stroke Trials Archive (VISTA) database to define the influence of infarct or hemorrhagic volume on clinical outcome after stroke.
METHODS: All patients were extracted from VISTA where infarct or hemorrhage volume information was available (n=2538; most images obtained by CT within 72 hours after stroke onset with a subset of MRI data included, volumes calculated by the ABC/2 approximation method). We used multivariate regression models to study the influence of age, National Institutes of Health Stroke Scale at baseline, and initial infarct/hemorrhage volume on clinical outcome (modified Rankin Scale, National Institutes of Health Stroke Scale, mortality) at day 90.
RESULTS: We find that in a large cohort of >1800 patients with ischemic stroke, initial lesion size is a strong and independent predictor of stroke outcome in a statistical regression model that also accounts for age and National Institutes of Health Stroke Scale at baseline (P<0.0001). The use of infarct/hemorrhage volume as an additional predictive factor further reduces the fraction of unexplained variance in outcome by approximately 15% (R(2) of 0.41 versus 0.26 in a model without lesion volume). The predictive strength of initial lesion size is only marginally influenced by image modality or time point of image acquisition within the first 72 hours. The model was equally valid for both ischemic and hemorrhagic strokes.
CONCLUSIONS: Infarct/hemorrhage volume at baseline together with age and National Institutes of Health Stroke Scale at baseline should be used in the effect analysis of future therapeutic stroke trials to improve power.
Gerhard Vogt; Rico Laage; Ashfaq Shuaib; Armin Schneider;
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Publication Detail:
Type:  Journal Article     Date:  2012-03-08
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  43     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-16     Revised Date:  2012-09-20    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1266-72     Citation Subset:  IM    
SYGNIS Bioscience, Heidelberg, Germany.
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MeSH Terms
Age Factors
Brain Infarction / pathology*
Cohort Studies
Databases, Factual*
Intracranial Hemorrhages / pathology*
Magnetic Resonance Imaging
Middle Aged
Predictive Value of Tests
Regression Analysis
Retrospective Studies
Stroke / diagnosis*,  pathology*
Time Factors
World Health*
A Alexandrov / ; P W Bath / ; E Bluhmki / ; L Claesson / ; J Curram / ; S M Davis / ; G Donnan / ; H C Diener / ; M Fisher / ; B Gregson / ; J Grotta / ; W Hacke / ; M G Hennerici / ; M Hommel / ; M Kaste / ; K R Lees / ; P Lyden / ; J Marler / ; K Muir / ; R Sacco / ; A Shuaib / ; P Teal / ; N G Wahlgren / ; S Warach / ; C Weimar /
Comment In:
Stroke. 2012 Aug;43(8):e75; author reply e76   [PMID:  22713490 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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