| Initial experience with tadalafil in pediatric pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 22402804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to investigate the safety, tolerability, and effects of tadalafil on children with pulmonary arterial hypertension (PAH) after transition from sildenafil or after tadalafil received as initial therapy. A total of 33 pediatric patients with PAH were retrospectively evaluated. Of the 33 patients, 29 were switched from sildenafil to tadalafil. The main reason for the change from sildenafil was once-daily dosing. The average dose of sildenafil was 3.4 ± 1.1 mg/kg/day, and that of tadalafil was 1.0 ± 0.4 mg/kg/day. For 14 of the 29 patients undergoing repeat catheterization, statistically significant improvements were observed after transition from sildenafil to tadalafil in terms of mean pulmonary arterial pressure (53.2 ± 18.3 vs. 47.4 ± 13.7 mmHg; p < 0.05) and pulmonary vascular resistance index (12.2 ± 7.0 vs 10.6 ± 7.2 Units/m(2); p < 0.05). Clinical improvement was noted for four patients treated with tadalafil as initial therapy. The side effect profiles were similar for the patients who had transitioned from sildenafil to tadalafil including headache, nausea, myalgia, nasal congestion, flushing, and allergic reaction. Two patients discontinued tadalafil due to migraine or allergic reaction. One patient receiving sildenafil had no breakthrough syncope after transition to tadalafil. Tadalafil can be safely used for pediatric patients with PAH and may prevent disease progression. |
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Authors:
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Shinichi Takatsuki; Michelle Calderbank; David Dunbar Ivy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-09 |
Journal Detail:
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Title: Pediatric cardiology Volume: 33 ISSN: 1432-1971 ISO Abbreviation: Pediatr Cardiol Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-24 Completed Date: 2012-10-24 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 683-8 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital Colorado University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO 80045, USA. tekeshin0621@msn.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Carbolines / administration & dosage, adverse effects, therapeutic use* Cardiac Output Child Child, Preschool Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Hypertension, Pulmonary / drug therapy* Male Phosphodiesterase 5 Inhibitors / administration & dosage, adverse effects, therapeutic use* Piperazines / therapeutic use Purines / therapeutic use Retrospective Studies Statistics, Nonparametric Sulfones / therapeutic use Treatment Outcome Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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P50 HL084923/HL/NHLBI NIH HHS; P50 HL084923-05S1/HL/NHLBI NIH HHS; UL1 RR025780/RR/NCRR NIH HHS; UL1 RR025780/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbolines; 0/Phosphodiesterase 5 Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/tadalafil; 3M7OB98Y7H/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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