| Initial experience with an institutional bridging protocol for patients with recent coronary stent implantation requiring discontinuation of dual antiplatelet therapy resulting from urgent surgery. | |
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MedLine Citation:
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PMID: 20634687 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Patients that receive coronary bare-metal or drug-eluting stents have to be maintained on dual antiplatelet therapy (DAPT) for at least 4 weeks or 12 months, respectively. The prolonged time period required for drug-eluting stents is the result of delayed vascular healing that is associated with the drug and the polymeric coating. Premature cessation of DAPT may precipitate life-threatening stent thrombosis. However, some urgent, unplanned surgical procedures cannot be carried out under DAPT as a result of an unacceptable bleeding risk. Therefore, in these particular patients, DAPT therapy needs to be bridged for urgent surgery to avoid stent thrombosis, yet no clinical recommendation about a specific pharmacologic protocol is currently available for this specific purpose. We report about the initial experience with a novel institutional bridging protocol using bivalirudin that has been developed and applied successfully in a limited number of patients. |
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Authors:
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Rainer Wessely |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of therapeutics Volume: 18 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
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Languages: eng Pagination: e280-2 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Angiology, Ev. Bethesda-Johanniter-Klinikum, Duisburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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