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Initial Clinical Assessment of a Novel Multifunctional Topical Ointment for Difficult-to-Heal Wounds: A Case Series.
MedLine Citation:
PMID:  23151766     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: Chronic wounds are characterized by prolonged inflammation, bacterial bioburden, and ischemia. These factors represent the barriers to wound healing that need to be addressed in order to achieve wound closure. The authors performed the initial clinical testing of WinVivo Wound Ointment ("WinVivo"), a novel topical ointment containing several botanicals that have been previously shown to promote favorable wound environment and advance wound healing. In this series of 13 patients with difficult-to-heal lower-extremity wounds, WinVivo was well tolerated and demonstrated the ability to simultaneously support granulation tissue formation; decrease the amount of exudate, edema, and malodor; and reduce pain. The ulcers included in this study have been present for a minimum of 3 weeks and a maximum of 5 years prior to the start of treatment with WinVivo. Eight of 13 wounds have previously been treated with at least 1 type of advanced wound healing modality, such as dermal substitutes or negative-pressure wound therapy. Treatment with WinVivo lasted for 3 to 12 weeks and resulted in a mean 88% wound closure, with 4 wounds healing completely. In addition to significant reduction in wound size, all patients have exhibited other clinical benefits, suggesting overall improvement in wound conditions. Future studies in a larger population, as well as case-control studies comparing WinVivo with a standard of care, are therefore warranted to further evaluate the efficacy of this new treatment.
Alexander M Reyzelman; Irina Bazarov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in skin & wound care     Volume:  25     ISSN:  1538-8654     ISO Abbreviation:  Adv Skin Wound Care     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911021     Medline TA:  Adv Skin Wound Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  557-60     Citation Subset:  N    
Alexander M. Reyzelman, DPM, is Associate Professor, Department of Medicine; and Irina Bazarov, MS, is a Podiatric Medical Student; both at the California School of Podiatric Medicine at Samuel Merritt University, Oakland, California.
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