Document Detail

Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy.
MedLine Citation:
PMID:  9595813     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.
S Daher; F Fonseca; R Mattar; C C Musatti; M G de Lima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  115     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1998-08-06     Completed Date:  1998-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1485-9     Citation Subset:  IM    
Pediatrics Department, Universidade Federal de São Paulo, EPM, Brazil.
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MeSH Terms
Abortion, Habitual / immunology*
Cell Division / immunology
Lymphocyte Culture Test, Mixed*
Lymphocyte Transfusion
Lymphocytes / cytology*
Pregnancy / blood*,  immunology*
Reg. No./Substance:

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