| Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity. | |
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MedLine Citation:
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PMID: 17658517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, negative effects of phosphatase in tumorigenesis and metastasis have been suggested in various tumor types. In this study, we showed that RhoA activation modulated phosphatase during senescence-like arrest in human prostate cancer cells. Under senescence-inducing condition, decreased Erk phosphorylation was detected in caRhoA-transfected cells and inactivation of Erk, but not p38, prevented doxorubicin-induced cell senescence. Cells were induced to senescence by inhibition of phosphatase activity (VHR, MKP3, or PP2A) without additional cellular stress. Of interest, caRhoA prevented doxorubicin-induced decrease of phosphatase. Thus, we postulate that RhoA signaling may protect cells against cellular senescence by maintaining phosphatase activity and Erk dephosphorylation. |
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Authors:
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Chaehwa Park; Inkyoung Lee; Jun Ho Jang; Won Ki Kang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-16 |
Journal Detail:
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Title: FEBS letters Volume: 581 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-09-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3800-4 Citation Subset: IM |
Affiliation:
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Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-gu, Seoul 135-710, Republic of Korea. cpark@smc.samsung.co.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology Cell Aging / physiology* Cell Cycle / physiology Cell Line, Tumor Doxorubicin / pharmacology Enzyme Activation Humans Male Mitogen-Activated Protein Kinase 3 / antagonists & inhibitors Phosphoric Monoester Hydrolases / metabolism* Phosphorylation Prostatic Neoplasms / metabolism, pathology Transfection rhoA GTP-Binding Protein / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 23214-92-8/Doxorubicin; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.6.5.2/rhoA GTP-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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