| Inhibitory mechanism of lycopene on cytokine expression in experimental pancreatitis. | |
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MedLine Citation:
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PMID: 21793844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen species (ROS) are important mediators to induce pancreatitis. Serum levels of antioxidant enzymes and carotenoids including lycopene are lower in patients with pancreatitis than those of healthy subjects. The cholecystokinin (CCK) analog cerulein induces similar pathologic events as shown in human pancreatitis. Recent studies show that high doses of cerulein activate NF-κB and induce the expression of inflammatory cytokines, in pancreatic acinar cells, which is mediated by the activation of NADPH oxidase. Lycopene functions as a very potent antioxidant to suppress the induction of inflammatory cytokines, in pancreatic acinar cells stimulated with cerulein. In this review, the possible beneficial effect of lycopene on experimental pancreatitis shall be discussed based on its antioxidant activity. |
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Authors:
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Hyeyoung Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1229 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-28 Completed Date: 2011-10-28 Revised Date: 2011-11-28 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 99-102 Citation Subset: IM |
Copyright Information:
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© 2011 New York Academy of Sciences. |
Affiliation:
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Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, South Korea. kim626@yonsei.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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pharmacology* Carotenoids / pharmacology* Cholecystokinin / metabolism Cytokines / metabolism* Humans NADPH Oxidase / metabolism NF-kappa B / metabolism Pancreatitis / metabolism* Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cytokines; 0/NF-kappa B; 0/Reactive Oxygen Species; 36-88-4/Carotenoids; 502-65-8/lycopene; 9011-97-6/Cholecystokinin; EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
Erratum In:
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Ann N Y Acad Sci. 2011 Oct;1234(1):175 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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