Document Detail

Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP.
MedLine Citation:
PMID:  10644988     Owner:  NLM     Status:  MEDLINE    
Gene targeting experiments have revealed that transcription factors such as c-Myb and GATA-1 play crucial roles during hematopoietic differentiation. c-Myb is necessary in the immature cells of almost every hematopoietic lineage and GATA-1 is essential for the development of the erythroid lineage. In addition, CREB-binding protein (CBP) acts as a transcriptional adapter for various transcription factors, including c-Myb and GATA-1. In this paper, we show that the transcription factors c-Myb and GATA-1 each inhibit the transcriptional activity of the other and that any possible bipartite complexes c-Myb, GATA-1, and CBP could be formed, but the tripartite complex was hardly formed. The exclusive binding of GATA-1 and c-Myb to CBP is probably the molecular basis for the mutual inhibition of their transcriptional activity. Our data suggest that cross-talk between these three factors might be important for hematopoietic differentiation and that CBP functions as a key molecule during the process.
T Takahashi; N Suwabe; P Dai; M Yamamoto; S Ishii; T Nakano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  19     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-07     Completed Date:  2000-02-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
CREB-Binding Protein
Cell Differentiation
DNA-Binding Proteins / chemistry,  physiology*
Erythroid Precursor Cells / physiology
Erythroid-Specific DNA-Binding Factors
GATA1 Transcription Factor
Nuclear Proteins / chemistry,  physiology*
Proto-Oncogene Proteins c-myb / chemistry,  physiology*
Trans-Activators / chemistry,  physiology*
Transcription Factors / chemistry,  physiology*
Transcription, Genetic
Reg. No./Substance:
0/Crebbp protein, mouse; 0/DNA-Binding Proteins; 0/Erythroid-Specific DNA-Binding Factors; 0/GATA1 Transcription Factor; 0/Gata1 protein, mouse; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins c-myb; 0/Trans-Activators; 0/Transcription Factors; EC Protein

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