Document Detail

Inhibitory and excitatory amino acids in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
MedLine Citation:
PMID:  7572048     Owner:  NLM     Status:  MEDLINE    
Neurolathyrism is caused by overconsumption of seeds containing 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP). Amino acids levels of cerebrospinal fluid (CSF) were studied in 50 patients with neurolathyrism and 12 healthy volunteers. The levels of excitatory amino acids glutamate and aspartate were 281% and 71% respectively of control values. The concentration of inhibitory amino acids glycine and taurine were 277% and 198% respectively of the levels in CSF from control individuals. There was a significant correlation between the level of glycine and the duration of the disease. We also found increased levels of threonine, serine and alanine. In contrast to reports on other motor neurone diseases where an increase of isoleucine was observed we found a significant decrease of isoleucine. The results suggest a disturbance of amino acid metabolism due to excitotoxic damages caused by beta-ODAP, a dietary excitatory amino acid.
J K Khan; Y H Kuo; A Haque; F Lambein
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  91     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  506-10     Citation Subset:  IM    
Laboratory of Physiological Chemistry, University of Ghent, Belgium.
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MeSH Terms
Alanine / cerebrospinal fluid*,  metabolism
Aspartic Acid / cerebrospinal fluid*,  metabolism
Excitatory Amino Acids / cerebrospinal fluid*,  metabolism
Fabaceae / adverse effects*,  metabolism
Glutamic Acid / cerebrospinal fluid*,  metabolism
Glycine / cerebrospinal fluid*,  metabolism
Isoleucine / cerebrospinal fluid*,  metabolism
Middle Aged
Motor Neuron Disease / cerebrospinal fluid*,  metabolism
Neurotoxins / adverse effects*,  metabolism
Plants, Medicinal*
Taurine / cerebrospinal fluid*,  metabolism
Threonine / cerebrospinal fluid*,  metabolism
Reg. No./Substance:
0/Excitatory Amino Acids; 0/Neurotoxins; 107-35-7/Taurine; 56-40-6/Glycine; 56-41-7/Alanine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 72-19-5/Threonine; 73-32-5/Isoleucine

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