Document Detail

Inhibitory effects of various progestins and deoxycorticosterone on the rapid onset of maternal behavior induced by ovariectomy-hysterectomy during late pregnancy in rats.
MedLine Citation:
PMID:  350746     Owner:  NLM     Status:  MEDLINE    
The inhibitory effects of progesterone (P), 5 alpha-dihydroprogesterone (5 alpha-DHP), 17 alpha-hydroxyprogesterone (17-HP), and deoxycorticosterone (DOC) upon the rapid onset of maternal behavior induced during late pregnancy in primigravid rats by ovariectomy-hysterectomy (OH) were examined. Progesterone administration at a dosage of 5.0 mg oil vehicle daily (beginning on Day 17 and ending when the subject responded maternally to foster pups) significantly delayed by about 1.5 to 2.0 days the onset of maternal behavior. In contrast, P at dosages of either 1.0 or 2.5 mg daily, 5 alpha-DHP at 5.0 mg administered daily in either an oil or Tween-80 vehicle, 17-HP at 5.0 mg in oil daily, and DOC at dosages of either 5.0 or 10.0 mg in oil daily failed to effect the rapid onset of maternal behavior induced by ovariectomy-hysterectomy on Day 17 of pregnancy. These data suggest that during pregnancy the onset of maternal behavior is inhibited in a rather specific manner by progesterone.
R S Bridges; H H Feder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormones and behavior     Volume:  10     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-08-28     Completed Date:  1978-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  30-9     Citation Subset:  IM    
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MeSH Terms
Algestone / pharmacology
Desoxycorticosterone / pharmacology*
Hydroxyprogesterones / pharmacology
Maternal Behavior*
Pregnancy, Animal*
Progesterone / pharmacology
Progestins / pharmacology*
Reg. No./Substance:
0/Hydroxyprogesterones; 0/Progestins; 57-83-0/Progesterone; 595-77-7/Algestone; 64-85-7/Desoxycorticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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