Document Detail

Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells.
MedLine Citation:
PMID:  18384089     Owner:  NLM     Status:  MEDLINE    
Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.
Anna-Kristina Marel; Gérard Lizard; Jean-Claude Izard; Norbert Latruffe; Dominique Delmas
Related Documents :
1998989 - Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat ca...
2691649 - Immunohistochemical localization of leu-m1 carbohydrate antigen in human oral squamous ...
2831179 - Dry mass, dna and non-histone protein determinations in lung cancer cells.
10704679 - Cytogenetic analysis of esophageal squamous cell carcinoma cell lines by comparative ge...
4318779 - Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cerv...
16510219 - Cardiac metastasis after squamous cell carcinoma of the oral cavity: case report.
11908669 - Mosaic haploid-diploid embryos and polyspermy in the tellinid bivalve macoma balthica.
2155419 - An immunohistochemical study of lung carcinomas using a monoclonal antibody which speci...
17821059 - Cesium in liriodendron and other woody species: organic bonding sites.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  52     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-08-06     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  538-48     Citation Subset:  IM    
INSERM U866, Dijon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Cycle / drug effects*
Cell Division / drug effects*
Cell Line, Tumor
Cell Membrane Permeability
Colonic Neoplasms / pathology*
DNA Replication / drug effects*
DNA, Neoplasm / drug effects,  metabolism
Flow Cytometry / methods
Stilbenes / pharmacology*
Structure-Activity Relationship
Xenobiotics / pharmacology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/DNA, Neoplasm; 0/Stilbenes; 0/Xenobiotics; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activati...
Next Document:  Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protect...