| Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. | |
| | |
MedLine Citation:
|
PMID: 18384089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma. |
| | |
Authors:
|
Anna-Kristina Marel; Gérard Lizard; Jean-Claude Izard; Norbert Latruffe; Dominique Delmas |
Related Documents
:
|
12205989 - The role of cellular trace elements in oral carcinogenesis induced by 4-nitroquinoline ... 15383669 - Endogenous formation of morphine in human cells. 12789909 - Keratinized squamous cells in fine needle aspiration of the brain. cytopathologic corre... 1384959 - Identification of a novel cd56- lymphokine-activated killer cell precursor in cancer pa... 8306659 - Suppression of human corneal epithelial proliferation with breast carcinoma immunotoxin. 11895859 - Apoptosis of squamous cells at different stages of carcinogenesis following 4-hpr treat... 7980519 - Biosynthesis and processing by phorbol ester of the cells surface-associated precursor ... 17972329 - Induction of chondrogenesis and superficial zone protein accumulation in synovial side ... 647759 - Differentiation of ovarian and testicular interstitial cells during embryonic and post-... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Molecular nutrition & food research Volume: 52 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-14 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 538-48 Citation Subset: IM |
Affiliation:
|
INSERM U866, Dijon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents, Phytogenic
/
pharmacology* Cell Cycle / drug effects* Cell Division / drug effects* Cell Line, Tumor Cell Membrane Permeability Colonic Neoplasms / pathology* DNA Replication / drug effects* DNA, Neoplasm / drug effects, metabolism Flow Cytometry / methods Humans Stilbenes / pharmacology* Structure-Activity Relationship Xenobiotics / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/DNA, Neoplasm; 0/Stilbenes; 0/Xenobiotics; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activati...
Next Document: Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protect...