Document Detail


Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells.
MedLine Citation:
PMID:  18384089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.
Authors:
Anna-Kristina Marel; Gérard Lizard; Jean-Claude Izard; Norbert Latruffe; Dominique Delmas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  52     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-08-06     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  538-48     Citation Subset:  IM    
Affiliation:
INSERM U866, Dijon, France.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Cycle / drug effects*
Cell Division / drug effects*
Cell Line, Tumor
Cell Membrane Permeability
Colonic Neoplasms / pathology*
DNA Replication / drug effects*
DNA, Neoplasm / drug effects,  metabolism
Flow Cytometry / methods
Humans
Stilbenes / pharmacology*
Structure-Activity Relationship
Xenobiotics / pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/DNA, Neoplasm; 0/Stilbenes; 0/Xenobiotics; Q369O8926L/resveratrol

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