| Inhibitory effects of topical thymoquinone on corneal neovascularization. | |
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MedLine Citation:
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PMID: 17592323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Thymoquinone, one of the biologically active components of black seed oil, has anti-inflammatory and antioxidant properties. We aimed to study the effect of thymoquinone on corneal neovascularization in rats and to compare its efficacy with that of triamcinolone acetonide. METHODS: Chemical cauterization of the cornea was performed with silver nitrate/potassium nitrate sticks in 40 eyes in 40 rats. An examiner blinded to the experiments scored the intensity of the cauterization. Topical instillation of thymoquinone 0.1%, thymoquinone 0.4%, and triamcinolone acetonide was continued for 7 days. The inhibitory effects of the drugs on corneal neovascularization were tested and compared with each other and with controls with a computer program that evaluates percent areas of cornea covered by neovascularization. RESULTS: The means of percent area of corneal neovascularization in the thymoquinone 0.1%, thymoquinone 0.4%, triamcinolone acetonide, and control groups were 60.1%, 45%, 46%, and 72%, respectively. The inhibitory effect of thymoquinone 0.4% was found to be equal to that of triamcinolone acetonide (P = 0.87). The thymoquinone 0.4% and triamcinolone groups were different from the thymoquinone 0.1% and control groups (P < 0.05). There was also a significant difference between the percent area of corneal neovascularization in the thymoquinone 0.1% group and that of the controls (P < 0.05). The mean burn stimulus intensities were not different among the groups (P = 0.54). CONCLUSIONS: Thymoquinone was shown to have an inhibitory effect, comparable with that of triamcinolone, on corneal neovascularization in this rat model. However, thymoquinone decreased corneal neovascularization in a dose-dependent manner. |
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Authors:
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Mesut Erdurmus; Ramazan Yagci; Bulent Yilmaz; Ibrahim F Hepsen; Cem Turkmen; Bahri Aydin; Remzi Karadag |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 715-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Fatih University Medical School, Ankara, Turkey. merdurmus@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / administration & dosage* Antioxidants / administration & dosage* Benzoquinones / administration & dosage* Corneal Neovascularization / prevention & control* Disease Models, Animal Dose-Response Relationship, Drug Male Rats Rats, Wistar Triamcinolone Acetonide / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Benzoquinones; 490-91-5/thymoquinone; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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