| Inhibitory effects of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) on myocardial infarction in rats. | |
| | |
MedLine Citation:
|
PMID: 9063769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The inhibitory effect of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) was examined in myocardial infarction induced in rats, in comparison with a selective 5-lipoxygenase inhibitor, AA-861. EPC-K1 significantly reduced the infarct size at 24 and 48 h after ligation, whereas AA-861 reduced it only at 48 h after ligation. In in-vitro experiments, EPC-K1 inhibited not only superoxide anion generation (IC50 = 4.2 x 10(-5) M), but also acid phosphatase activity (IC50 = 2.4 x 10(-5) M) in rat polymorphonuclear leukocytes in a concentration-dependent manner, while AA-861 showed marginal effects on both actions. These results indicated that EPC-K1 induced cardioprotective effects by affecting neutrophil functions by inhibition of generation of superoxide-anion generation and acid-phosphatase activity. The mechanism of the reduction of the infarct size by EPC-K1 differed from that of AA-861, which latter inhibited 5-lipoxygenase and the formation of leukotriene B4. |
| | |
Authors:
|
Y Kuribayashi; M Katori; M Majima; K Yoshida |
Related Documents
:
|
6360139 - Cytochemical identification of the leukocytes of torpedoes (torpedo marmorata risso and... 3037369 - Phosphomonoesterases of leishmania mexicana mexicana and other flagellates. 7024959 - Clinical significance of serum and bone marrow acid phosphatase. 207329 - The effect of different buffers on terminal deoxynucleotidyl transferase activity. 22547329 - Effectivity of freeze-dried form of lactobacillus fermentum ad1-ccm7421 in dogs. 2592149 - Decrease of acid phosphatase activity in murine peritoneal macrophages infected with le... 10950299 - Separation of gallic acid from cornus officinalis sieb. et zucc by high-speed counter-c... 522229 - Fatty acid content of depot fat in the northern fur seal (callorhinus ursinus). 18969059 - Determination of tyrosine through a fia-direct chemiluminescence procedure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of tissue reactions Volume: 18 ISSN: 0250-0868 ISO Abbreviation: Int J Tissue React Publication Date: 1996 |
Date Detail:
|
Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2010-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 8302116 Medline TA: Int J Tissue React Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / pharmacology* Arachidonate 5-Lipoxygenase / antagonists & inhibitors Ascorbic Acid / analogs & derivatives*, pharmacology Benzoquinones / pharmacology Free Radical Scavengers / pharmacology* Lipoxygenase Inhibitors / pharmacology Lysosomes / enzymology Male Myocardial Infarction / prevention & control* Peroxidase / metabolism Rats Rats, Sprague-Dawley Superoxides / metabolism Vitamin E / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Benzoquinones; 0/Free Radical Scavengers; 0/Lipoxygenase Inhibitors; 11062-77-4/Superoxides; 127061-56-7/EPC-K(1); 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 80809-81-0/2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; EC 1.11.1.7/Peroxidase; EC 1.13.11.34/Arachidonate 5-Lipoxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after shor...
Next Document: Immunodepression induced by carbamazepine administration is mediated by CD 8+ spleen T cells.