Document Detail


Inhibitory effects of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) on myocardial infarction in rats.
MedLine Citation:
PMID:  9063769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) was examined in myocardial infarction induced in rats, in comparison with a selective 5-lipoxygenase inhibitor, AA-861. EPC-K1 significantly reduced the infarct size at 24 and 48 h after ligation, whereas AA-861 reduced it only at 48 h after ligation. In in-vitro experiments, EPC-K1 inhibited not only superoxide anion generation (IC50 = 4.2 x 10(-5) M), but also acid phosphatase activity (IC50 = 2.4 x 10(-5) M) in rat polymorphonuclear leukocytes in a concentration-dependent manner, while AA-861 showed marginal effects on both actions. These results indicated that EPC-K1 induced cardioprotective effects by affecting neutrophil functions by inhibition of generation of superoxide-anion generation and acid-phosphatase activity. The mechanism of the reduction of the infarct size by EPC-K1 differed from that of AA-861, which latter inhibited 5-lipoxygenase and the formation of leukotriene B4.
Authors:
Y Kuribayashi; M Katori; M Majima; K Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of tissue reactions     Volume:  18     ISSN:  0250-0868     ISO Abbreviation:  Int J Tissue React     Publication Date:  1996  
Date Detail:
Created Date:  1997-06-09     Completed Date:  1997-06-09     Revised Date:  2010-05-07    
Medline Journal Info:
Nlm Unique ID:  8302116     Medline TA:  Int J Tissue React     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Arachidonate 5-Lipoxygenase / antagonists & inhibitors
Ascorbic Acid / analogs & derivatives*,  pharmacology
Benzoquinones / pharmacology
Free Radical Scavengers / pharmacology*
Lipoxygenase Inhibitors / pharmacology
Lysosomes / enzymology
Male
Myocardial Infarction / prevention & control*
Peroxidase / metabolism
Rats
Rats, Sprague-Dawley
Superoxides / metabolism
Vitamin E / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Benzoquinones; 0/Free Radical Scavengers; 0/Lipoxygenase Inhibitors; 11062-77-4/Superoxides; 127061-56-7/EPC-K(1); 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 80809-81-0/2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; EC 1.11.1.7/Peroxidase; EC 1.13.11.34/Arachidonate 5-Lipoxygenase

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