Document Detail

Inhibitory effects of phenolics, teas and saliva on the formation of mutagenic nitrosation products of salted fish.
MedLine Citation:
PMID:  7160941     Owner:  NLM     Status:  MEDLINE    
The objectives of this study were to simulate in vitro some of the conditions that may prevail in man during the ingestion of a meal and to quantitate the inhibitory effect of phenolics and phenolic-containing beverages on the formation of mutagenic nitrosation products. The test system consisted of nitrosating (pH 2, 1 h, 37 degrees C) an aqueous fraction of a salt-preserved Chinese fish (Pak Wik) with or without the inhibitors to be tested and estimating the frequency of his+ revertants per survivor of Salmonella typhimurium (strain TA1535). The phenolics and teas were added to the nitrosation mixture. Catechin, chlorogenic acid, gallic acid, pyrogallol and tannic acid suppressed the formation of mutagenic nitrosation products. The inhibitory efficiency was comparable to that of ascorbic acid. A Japanese, a Chinese and a Ceylonese tea also prevented the formation of mutagenic nitrosated fish products at doses which are usually consumed by man. Moreover, saliva exerted an inhibitory effect. The inhibitory effect was not additive when the phenolics or saliva were added concurrently to the nitrosation mixture. The possibility that phenolics are involved in the apparent chemopreventive effect of fruits and vegetables is discussed.
H F Stich; P K Chan; M P Rosin
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  30     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  719-24     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / pharmacology
Catechin / pharmacology
Food Preservation*
Mutagens / metabolism*
Nitrites / pharmacology*
Phenols / pharmacology
Saliva / physiology
Sodium Nitrite / metabolism,  pharmacology*
Reg. No./Substance:
0/Mutagens; 0/Nitrites; 0/Phenols; 0/Tea; 154-23-4/Catechin; 50-81-7/Ascorbic Acid; 7632-00-0/Sodium Nitrite

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