Document Detail


Inhibitory effects of para-aminobenzoic acid on the formation and mutagenicity of N-nitroso compounds.
MedLine Citation:
PMID:  3062321     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Naturally occurring para-aminobenzoic acid (PABA) inhibited the formation of N-methyl-N-nitrosourea (MNU) from a nitrosation mixture of N-methylurea and nitrite at pH 3. The suppressive effect of PABA on the formation of MNU is higher than that of ascorbic acid. The presence of the MNU was assayed by its mutagenicity in a higher plant, Arabidopsis thaliana. In addition, PABA markedly reduced the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine in A.thaliana, but had no or only a low inhibitory effect on the mutagenicity of preformed MNU and on the promutagen N-nitrosodimethylamine.
Authors:
T Gichner; J Velemínský
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutagenesis     Volume:  3     ISSN:  0267-8357     ISO Abbreviation:  Mutagenesis     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-02-22     Completed Date:  1989-02-22     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8707812     Medline TA:  Mutagenesis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Affiliation:
Institute of Experimental Botany, Praha, Czechoslovakia.
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MeSH Terms
Descriptor/Qualifier:
4-Aminobenzoic Acid / pharmacology*
Aminobenzoic Acids / pharmacology*
Ascorbic Acid / pharmacology
Biotransformation
Dimethylnitrosamine / pharmacology
Methylnitronitrosoguanidine / pharmacology
Methylnitrosourea / metabolism*,  pharmacology
Methylurea Compounds / metabolism*
Mutagenicity Tests / methods
Mutation*
Nitrites / metabolism*
Nitroso Compounds / pharmacology*
Plants / drug effects,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Aminobenzoic Acids; 0/Methylurea Compounds; 0/Nitrites; 0/Nitroso Compounds; 150-13-0/4-Aminobenzoic Acid; 50-81-7/Ascorbic Acid; 598-50-5/methylurea; 62-75-9/Dimethylnitrosamine; 684-93-5/Methylnitrosourea; 70-25-7/Methylnitronitrosoguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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