Document Detail


Inhibitory effects of oxatomide on intracellular Ca mobilization, Ca uptake and histamine release, using rat peritoneal mast cells.
MedLine Citation:
PMID:  2440814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxatomide at concentrations of 0.01-10 microM inhibited not only an increase in 45Ca uptake but also the intracellular Ca2+ release induced by compound 48/80 in rat peritoneal mast cells. At higher concentrations, ketotifen or other calcium antagonists caused similar inhibitory effects. However, the inhibitory effect of oxatomide on the 45Ca uptake into rat neonatal heart cells was much weaker than that of verapamil. Through image processing of quin 2-stained mast cells, it was revealed that oxatomide inhibited Ca2+ release from the intracellular store. Although oxatomide alone did not affect cAMP and cGMP contents in sensitized guinea pig lung samples, the drug effectively prevented changes in the nucleotide contents evoked by antigen challenge. These results suggest that the inhibitory effect of oxatomide on histamine release may be caused by a combination of prevention of Ca uptake, which is highly selective toward mast cells; inhibition of Ca2+ release from the intracellular Ca store, and elevation of the cAMP content in mast cells.
Authors:
K Tasaka; M Akagi; M Mio; K Miyoshi; N Nakaya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  83     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-15     Completed Date:  1987-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoquinolines / diagnostic use
Animals
Calcium / metabolism*
Calcium Radioisotopes / diagnostic use
Cells, Cultured
Cyclic AMP / metabolism
Dose-Response Relationship, Drug
Guinea Pigs
Histamine H1 Antagonists / pharmacology*
Histamine Release / drug effects*
Image Interpretation, Computer-Assisted
Ion Channels / drug effects
Ketotifen / pharmacology
Lung / immunology,  metabolism
Male
Mast Cells / drug effects*
Microscopy, Fluorescence / methods
Myocardium / cytology,  metabolism
Peritoneal Cavity / cytology*
Piperazines / pharmacology*
Rats
Rats, Inbred Strains
p-Methoxy-N-methylphenethylamine / pharmacology
Chemical
Reg. No./Substance:
0/Aminoquinolines; 0/Calcium Radioisotopes; 0/Histamine H1 Antagonists; 0/Ion Channels; 0/Piperazines; 34580-13-7/Ketotifen; 4091-50-3/p-Methoxy-N-methylphenethylamine; 60-92-4/Cyclic AMP; 60607-34-3/oxatomide; 7440-70-2/Calcium; 83014-44-2/Quin2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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