Document Detail


Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities.
MedLine Citation:
PMID:  9389579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to determine the effects of single unsaturated fatty acids (UFAs) or combinations on establishment of lung metastatic colonies, UFAs were administered orally to CDF1 mice bearing s.c. implants of the highly metastatic colon carcinoma 26. Oleic acid (OA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) demonstrated significant inhibition. In the case of DHA, this inhibitory potential was markedly reduced by co-administration of linoleic acid (LA) or EPA. Furthermore, while tumor cells treated with DHA showed a very low potential for lung colony formation when injected i.v., this again being partially reversed by co-administration of EPA. UFAs were found to be well absorbed into tumor tissues after oral administration, causing marked changes in relative levels, the arachidonic acid (AA) content, in particular, being markedly decreased by treatment with DHA or EPA, but not with DHA plus EPA or with DHA plus LA. Investigation of the gelatinolytic activity of the 57-kDa and 92-kDa isoforms of type-IV collagenase (MMP-2 and MMP-9, respectively) showed a clear reduction in the former by treatment with OA, while DHA, but not DHA plus LA or EPA, caused a decrease in the 92-kDa isoform, which was well correlated with AA content in tumor tissues (r = 0.900, p < 0.001). These results suggest that inhibition of metastasis due to treatment with OA and DHA might be due to depressed type-IV collagenase activity.
Authors:
I Suzuki; M Iigo; C Ishikawa; T Kuhara; M Asamoto; T Kunimoto; M A Moore; K Yazawa; E Araki; H Tsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  73     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-10     Completed Date:  1997-12-10     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Affiliation:
Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / metabolism
Carcinoma / metabolism*,  prevention & control,  secondary*
Collagenases / metabolism*
Colonic Neoplasms / pathology*
Docosahexaenoic Acids / pharmacology*
Drug Screening Assays, Antitumor
Eicosapentaenoic Acid / pharmacology
Gelatinases / metabolism*
Lung Neoplasms / metabolism*,  prevention & control,  secondary*
Male
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Metalloendopeptidases / metabolism*
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Oleic Acid / pharmacology*
Tumor Cells, Cultured / drug effects
Tumor Stem Cell Assay
Chemical
Reg. No./Substance:
112-80-1/Oleic Acid; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; EC 3.4.24.-/Collagenases; EC 3.4.24.-/Gelatinases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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