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Inhibitory effects of noscapine on dopamine biosynthesis in PC12 cells.
MedLine Citation:
PMID:  18982500     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The effects of noscapine, a phthalide isoquinoline alkaloid, on dopamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells were investigated. Noscapine showed 74.6% inhibition on dopamine content in PC12 cells at a concentration of 20 muM. IC(50) of noscapine was 6.8 muM. TH activity was inhibited by the treatment of noscapine in PC12 cells (20.9% inhibition at 20 muM). Therefore, the inhibition of TH activity by noscapine might be involved in at least one component of the reduction of dopamine biosynthesis in PC12 cells.
Authors:
J S Shin; S S Lee; M K Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  20     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  2008-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  510-2     Citation Subset:  -    
Affiliation:
College of Pharmacy, Chungbuk National University, San 48, Kaeshin-Dong, 361-763, Cheongju, Korea.
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