Document Detail


Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs.
MedLine Citation:
PMID:  18945955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the effects and mechanisms of intestinal electrical stimulation (IES) on gastric tone, antral and pyloric contractions, and gastric emptying in dogs. Female hound dogs were equipped with a duodenal or gastric cannula, and one pair of serosal electrodes was implanted in the small intestine. The study consisted of five different experiments. Liquid gastric emptying was assessed by collection of chyme from the duodenal cannula in a number of sessions with and without IES and with and without N-nitro-l-arginine (l-NNA). Postprandial antral and pyloric contractions were measured with and without IES and in the absence and presence of l-NNA or phentolamine by placement of a manometric catheter into the antrum and pylorus via the duodenal cannula. Gastric tone was assessed by measurement of gastric volume at a constant pressure. Gastric emptying was substantially and significantly delayed by IES or l-NNA compared with the control session. IES-induced delay of gastric emptying became normal with addition of l-NNA. IES reduced gastric tone, which was blocked by l-NNA. IES also inhibited antral contractions (frequency and amplitude), and this inhibitory effect was not blocked by l-NNA but was blocked by phentolamine. IES alone did not affect pyloric tone or resistance, but IES + l-NNA decreased pyloric tone. In conclusion, IES reduces gastric tone via the nitrergic pathway, inhibits antral contractions via the adrenergic pathway, does not affect pyloric tone, and delays liquid gastric emptying. IES-induced delay of gastric emptying is attributed to its inhibitory effects on gastric motility.
Authors:
Xiaotuan Zhao; Jieyun Yin; Jihong Chen; Gengqing Song; Lijie Wang; Hongbing Zhu; Doug Brining; Jiande D Z Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-10-22
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-02-06     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R36-42     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0632, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / physiology
Adrenergic alpha-Antagonists / pharmacology
Animals
Dogs
Electric Stimulation
Enteric Nervous System / drug effects,  physiology*
Enzyme Inhibitors / pharmacology
Female
Gastric Emptying* / drug effects
Intestines / innervation*
Manometry
Muscle Contraction* / drug effects
Neural Inhibition
Nitrergic Neurons / physiology
Nitric Oxide Synthase / antagonists & inhibitors
Nitroarginine / pharmacology
Phentolamine / pharmacology
Postprandial Period
Pressure
Pyloric Antrum / drug effects,  innervation*
Pylorus / innervation*
Time Factors
Grant Support
ID/Acronym/Agency:
DK-063733/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Enzyme Inhibitors; 2149-70-4/Nitroarginine; 50-60-2/Phentolamine; EC 1.14.13.39/Nitric Oxide Synthase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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