Document Detail


Inhibitory effects of intravenous lansoprazole on gastric acid hypersecretion in patients with postoperative stress.
MedLine Citation:
PMID:  7594333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effects of intravenous lansoprazole on gastric acid hypersecretion caused by stress after surgical invasion were studied in patients who underwent surgery under general anesthesia for gastrointestinal diseases. Patients in this study received either 15 mg or 30 mg of lansoprazole by slow intravenous injection twice daily for 3 days (six injections). The total number of patients studied was 82, with 41 patients in each group. Intragastric pH was measured every 8 h after the start of administration, and the inhibitory effects of intravenous lansoprazole on postoperative gastric acid secretion were evaluated using four grades: excellent, good, fair, and poor. In the 15-mg group, 65.8% (25 of 38 patients) were classified as good or excellent, and in the 30-mg group, 75.7% (28 of 37 patients) were good or excellent. No adverse effects directly attributable to the administration of lansoprazole were observed.
Authors:
Y Otani; M Kitajima; M Sugiyama; Y Watanabe; T Aoki
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  20 Suppl 2     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S22-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles
Adolescent
Adult
Aged
Anti-Ulcer Agents / administration & dosage,  pharmacology*
Female
Gastric Acid / secretion*
Humans
Injections, Intravenous
Male
Middle Aged
Omeprazole / administration & dosage,  analogs & derivatives*,  pharmacology
Peptic Ulcer Hemorrhage / prevention & control
Postoperative Complications
Proton Pumps / antagonists & inhibitors*
Stomach Ulcer / prevention & control
Stress, Physiological / physiopathology*
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Proton Pumps; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole

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