| Inhibitory effects of intravenous lansoprazole on gastric acid hypersecretion in patients with postoperative stress. | |
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MedLine Citation:
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PMID: 7594333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inhibitory effects of intravenous lansoprazole on gastric acid hypersecretion caused by stress after surgical invasion were studied in patients who underwent surgery under general anesthesia for gastrointestinal diseases. Patients in this study received either 15 mg or 30 mg of lansoprazole by slow intravenous injection twice daily for 3 days (six injections). The total number of patients studied was 82, with 41 patients in each group. Intragastric pH was measured every 8 h after the start of administration, and the inhibitory effects of intravenous lansoprazole on postoperative gastric acid secretion were evaluated using four grades: excellent, good, fair, and poor. In the 15-mg group, 65.8% (25 of 38 patients) were classified as good or excellent, and in the 30-mg group, 75.7% (28 of 37 patients) were good or excellent. No adverse effects directly attributable to the administration of lansoprazole were observed. |
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Authors:
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Y Otani; M Kitajima; M Sugiyama; Y Watanabe; T Aoki |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 20 Suppl 2 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S22-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Medicine, Keio University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles Adolescent Adult Aged Anti-Ulcer Agents / administration & dosage, pharmacology* Female Gastric Acid / secretion* Humans Injections, Intravenous Male Middle Aged Omeprazole / administration & dosage, analogs & derivatives*, pharmacology Peptic Ulcer Hemorrhage / prevention & control Postoperative Complications Proton Pumps / antagonists & inhibitors* Stomach Ulcer / prevention & control Stress, Physiological / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Proton Pumps; 103577-45-3/lansoprazole; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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