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Inhibitory effects of geranic acid derivatives on melanin biosynthesis.
MedLine Citation:
PMID:  23286867     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The effects of geranic acid and its structurally related derivatives (geraniol, citronellic acid, and citronellol) on cell viability and melanin biosynthesis in Melan-a cells were evaluated in this study. Among them, geranic acid evidenced the strongest inhibitory activity on melanin production, coupled with low cell toxicity. Treatment with 500 μM of this compound resulted in a reduction in melanin content of 35.4% as compared to the live cell percentage (91.7%). Moreover, geranic acid also inhibited tyrosinase activity and intracellular tyrosinase expression in a dose-dependent manner. These results show that geranic acid may function as a skin depigmenting agent via the inhibition of tyrosinase activity and expression within melanocytes.
Authors:
Sang Yoon Choi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cosmetic science     Volume:  63     ISSN:  1525-7886     ISO Abbreviation:  J Cosmet Sci     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2013-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814276     Medline TA:  J Cosmet Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  IM    
Affiliation:
Korea Food Research Institute, Seongnam, Gyenoggi 463-746, Korea.
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