| Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta. | |
| | |
MedLine Citation:
|
PMID: 9200557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dimalonic acid C60 (10(-5) M), a new fullerene derivative, produced an augmentation of phenylephrine-induced tone and reduced both the acetylcholine-induced maximum relaxation and the amplitude of substance P (10(-8) M)-induced relaxation in endothelium-containing thoracic aorta of rabbit; the acetylcholine- and substance P-induced relaxation was restored in the presence of superoxide dismutase (250 U/ml). Dimalonic acid C60 (10(-5) M) did not influence the phenylephrine-induced contractile response in the absence of endothelium, but the acetylcholine-induced relaxation was eliminated by removal of the endothelium. Superoxide anion generation, using hypoxanthine (1 mM)/xanthine oxidase (16 mU/ml), reduced the acetylcholine-induced relaxation and produced an augmentation of phenylephrine-induced tone in endothelium-containing strips; these effects were negated by the addition of superoxide dismutase (250 U/ml). A nitric oxide-generating agent, S-nitroso-N-acetylpenicillamine, caused relaxation of aorta without endothelium in a concentration-dependent manner, and the concentration-response curve was shifted to the right in the presence of dimalonic acid C60. This inhibitory effect of dimalonic acid C60 was also masked in the presence of superoxide dismutase. Sodium nitroprusside-induced relaxation was not affected by either dimalonic acid C60 or superoxide dismutase. These observations suggest that dimalonic acid C60 inhibits endothelium (nitric oxide)-dependent agonist-induced relaxation through the production of superoxide. |
| | |
Authors:
|
M Satoh; K Matsuo; H Kiriya; T Mashino; T Nagano; M Hirobe; I Takayanagi |
Related Documents
:
|
8395827 - Combination of arachidonic acid and guanosine 5'-o-(3-thiotriphosphate) induce transloc... 17156977 - A csf and postmortem brain study of d-serine metabolic parameters in schizophrenia. 6147057 - High-performance liquid chromatographic analysis of analogous amino and oxo acids for t... 1680747 - Administration of d-alanine did not cause increase of d-amino acid oxidase activity in ... 16448157 - Determination of total content of phenolic compounds and their antioxidant activity in ... 2879567 - On the mechanism of linolenic acid inhibition in photosystem ii. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 327 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-08-18 Completed Date: 1997-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 175-81 Citation Subset: IM |
Affiliation:
|
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan. satoh@phar.toho-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
antagonists & inhibitors* Animals Aorta / drug effects Endothelium, Vascular / drug effects Male Malonates / pharmacology* Muscle Relaxation / drug effects* Muscle, Smooth, Vascular / drug effects* Nitric Oxide / antagonists & inhibitors*, pharmacology Phenylephrine Rabbits Superoxide Dismutase / metabolism Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Malonates; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 159717-74-5/dimalonic acid C(60); 51-84-3/Acetylcholine; 59-42-7/Phenylephrine; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-alpha, ameliorates endotoxin-i...
Next Document: Effects of endothelin-1 on arterial and venous resistances in anaesthetized rats.