Document Detail


Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta.
MedLine Citation:
PMID:  9200557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dimalonic acid C60 (10(-5) M), a new fullerene derivative, produced an augmentation of phenylephrine-induced tone and reduced both the acetylcholine-induced maximum relaxation and the amplitude of substance P (10(-8) M)-induced relaxation in endothelium-containing thoracic aorta of rabbit; the acetylcholine- and substance P-induced relaxation was restored in the presence of superoxide dismutase (250 U/ml). Dimalonic acid C60 (10(-5) M) did not influence the phenylephrine-induced contractile response in the absence of endothelium, but the acetylcholine-induced relaxation was eliminated by removal of the endothelium. Superoxide anion generation, using hypoxanthine (1 mM)/xanthine oxidase (16 mU/ml), reduced the acetylcholine-induced relaxation and produced an augmentation of phenylephrine-induced tone in endothelium-containing strips; these effects were negated by the addition of superoxide dismutase (250 U/ml). A nitric oxide-generating agent, S-nitroso-N-acetylpenicillamine, caused relaxation of aorta without endothelium in a concentration-dependent manner, and the concentration-response curve was shifted to the right in the presence of dimalonic acid C60. This inhibitory effect of dimalonic acid C60 was also masked in the presence of superoxide dismutase. Sodium nitroprusside-induced relaxation was not affected by either dimalonic acid C60 or superoxide dismutase. These observations suggest that dimalonic acid C60 inhibits endothelium (nitric oxide)-dependent agonist-induced relaxation through the production of superoxide.
Authors:
M Satoh; K Matsuo; H Kiriya; T Mashino; T Nagano; M Hirobe; I Takayanagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  327     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-18     Completed Date:  1997-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
Affiliation:
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan. satoh@phar.toho-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / antagonists & inhibitors*
Animals
Aorta / drug effects
Endothelium, Vascular / drug effects
Male
Malonates / pharmacology*
Muscle Relaxation / drug effects*
Muscle, Smooth, Vascular / drug effects*
Nitric Oxide / antagonists & inhibitors*,  pharmacology
Phenylephrine
Rabbits
Superoxide Dismutase / metabolism
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Malonates; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 159717-74-5/dimalonic acid C(60); 51-84-3/Acetylcholine; 59-42-7/Phenylephrine; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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