Document Detail


Inhibitory effects of foods and polyphenols on activation of aryl hydrocarbon receptor induced by diesel exhaust particles.
MedLine Citation:
PMID:  17622219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The toxicity of endocrine disrupters is involved in the activation of the aryl hydrocarbon receptor (AhR). We examined the toxicity of diesel exhaust particles (DEPs) using the Ah immunoassay (Ah-I) to study the inhibitory effects of various foods and polyphenols on DEP-induced AhR activation. The toxicity equivalent of DEP was 6,479 +/-58 ng dioxin toxicity equivalent/g (DEQ/g). The relationship between DEP dose and AhR activation was linear up to 27.8 microg/ml. Ginkgo biloba extract (GBE) had the strongest inhibitory effect on DEP-induced AhR activation. Quercetin, a major polyphenol in onions, and GBE showed a strong inhibitory effect. These results show that the DEP-induced AhR activation can be assessed using Ah-I and that the assay is suitable for determining the dioxin toxicity equivalent of DEP. In addition, Ah-I is also effective for screening food and its components that inhibit DEP-induced AhR activation.
Authors:
Hiromi Izawa; Gen Watanabe; Kazuyoshi Taya; Masaru Sagai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental sciences : an international journal of environmental physiology and toxicology     Volume:  14     ISSN:  0915-955X     ISO Abbreviation:  Environ Sci     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-11     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209787     Medline TA:  Environ Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Affiliation:
Division of Human Sciences, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan. h_izawa@auhw.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / toxicity*
Camellia sinensis
Dioxins / toxicity
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Flavonoids / pharmacology*
Garlic
Ginkgo biloba
Onions
Phenols / pharmacology*
Plant Extracts / pharmacology*
Receptors, Aryl Hydrocarbon / agonists*,  antagonists & inhibitors
Vehicle Emissions / toxicity*
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Dioxins; 0/Flavonoids; 0/Phenols; 0/Plant Extracts; 0/Receptors, Aryl Hydrocarbon; 0/Vehicle Emissions; 0/polyphenols

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