Document Detail

Inhibitory effects of foods and polyphenols on activation of aryl hydrocarbon receptor induced by diesel exhaust particles.
MedLine Citation:
PMID:  17622219     Owner:  NLM     Status:  MEDLINE    
The toxicity of endocrine disrupters is involved in the activation of the aryl hydrocarbon receptor (AhR). We examined the toxicity of diesel exhaust particles (DEPs) using the Ah immunoassay (Ah-I) to study the inhibitory effects of various foods and polyphenols on DEP-induced AhR activation. The toxicity equivalent of DEP was 6,479 +/-58 ng dioxin toxicity equivalent/g (DEQ/g). The relationship between DEP dose and AhR activation was linear up to 27.8 microg/ml. Ginkgo biloba extract (GBE) had the strongest inhibitory effect on DEP-induced AhR activation. Quercetin, a major polyphenol in onions, and GBE showed a strong inhibitory effect. These results show that the DEP-induced AhR activation can be assessed using Ah-I and that the assay is suitable for determining the dioxin toxicity equivalent of DEP. In addition, Ah-I is also effective for screening food and its components that inhibit DEP-induced AhR activation.
Hiromi Izawa; Gen Watanabe; Kazuyoshi Taya; Masaru Sagai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental sciences : an international journal of environmental physiology and toxicology     Volume:  14     ISSN:  0915-955X     ISO Abbreviation:  Environ Sci     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-11     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209787     Medline TA:  Environ Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
Division of Human Sciences, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan.
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MeSH Terms
Air Pollutants / toxicity*
Camellia sinensis
Dioxins / toxicity
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Flavonoids / pharmacology*
Ginkgo biloba
Phenols / pharmacology*
Plant Extracts / pharmacology*
Receptors, Aryl Hydrocarbon / agonists*,  antagonists & inhibitors
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Air Pollutants; 0/Dioxins; 0/Flavonoids; 0/Phenols; 0/Plant Extracts; 0/Receptors, Aryl Hydrocarbon; 0/Vehicle Emissions; 0/polyphenols

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