Document Detail


Inhibitory effects of diterpene acids from root of Aralia cordata on IgE-mediated asthma in guinea pigs.
MedLine Citation:
PMID:  20060054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluated the anti-asthmatic activities of four diterpene acids isolated from Aralia cordata root that are proposed to be the active ingredients in its traditional use as a treatment for inflammation, overheating, pain and spasm in Korea. The diterpene acids were identified as kaurenoic acid, 7-oxo-sandaracopimaric acid, 17-hydroxy-ent-kaur-15-en-19-oic acid, and hederagenin, by comparing their phytochemical and spectroscopic data with previous reports. The effects of diterpene acids on asthma were evaluated by determining the specific airway resistance (sRaw) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with IgE-mediated asthma. Recruitment of leukocytes and the presence of chemical mediators in bronchoalveolar lavage fluid (BALF) were determined, and histopathological surveys performed. The four diterpene acids dosed at 25 approximately 100 mg/kg had dose-dependently anti-asthmatic effects: 7-oxo-sandaracopimaric acid > 17-hydroxy-ent-kaur-15-en-19-oic acid > kaurenoic acid > hederagenin. 7-oxo-sandaracopimaric acid (25 mg/kg) significantly (p < 0.05) inhibited sRaw by 59.5% in IAR and LAR, and also dose-dependently inhibited recruitment of eosinophils and neutrophils into lung and release of chemical mediators, histamine, and the activity of phospholipase A(2) and eosinophil peroxidase in BALF. 7-Oxo-sandaracopimaric acid had the highest activity among the diterpene acids. But its effect was lower than cromolyn sodium, salbutamol, or dexamethasone in both the IAR and the LAR. These results suggested that C(7)-oxo radical of 7-oxo-sandaracopimaric acid was more active than the C(7)-hydroxy and hydrogen of the other compounds, and showed diterpene acids have anti-asthmatic effects, supporting the traditional application of this herb in treating IgE-mediated asthma.
Authors:
Joong Hyung Cho; Ji Yun Lee; Sang Soo Sim; Wan Kyun Whang; Chang Jong Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-06
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  23     ISSN:  1522-9629     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  190-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
Division of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / drug effects
Animals
Aralia*
Asthma / drug therapy*
Bronchoalveolar Lavage Fluid / immunology
Diterpenes / pharmacology*
Dose-Response Relationship, Drug
Eosinophils / metabolism
Guinea Pigs
Histamine / metabolism
Immunoglobulin E / metabolism*
Leukocytes / metabolism
Male
Neutrophils / metabolism
Oleanolic Acid / analogs & derivatives,  pharmacology
Phospholipases A2 / metabolism
Plant Extracts / pharmacology
Chemical
Reg. No./Substance:
0/Diterpenes; 0/Plant Extracts; 35030-38-7/17-hydroxy-ent-kaur-15-en-19-oic acid; 37341-29-0/Immunoglobulin E; 465-99-6/hederagenin; 508-02-1/Oleanolic Acid; 51-45-6/Histamine; 6730-83-2/kaurenoic acid; EC 3.1.1.4/Phospholipases A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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