Document Detail

Inhibitory effects of cinnamic acid on melanin biosynthesis in skin.
MedLine Citation:
PMID:  18451524     Owner:  NLM     Status:  MEDLINE    
Cinnamic acid is a wildly distributed phenylpropanoid component naturally occurring in plants, and is mainly found in Cinnamomum cassia BLUME and Panax ginseng. Cinnamic acid was recently reported to exert a tyrosinase inhibitory effect. However, research on melanocytes and animal bodies was not reported until now. In this study, we examined the effects of cinnamic acid on melanin biosynthesis within the melanocytes and brown guinea pigs. Melan-a cells were used to examine the effects of cinnamic acid in the melanocytes. Treatment with 100 ppm of cinnamic acid resulted in a significant reduction of melanin production in the melan-a cells at 29.0%. This compound also exhibited a potent inhibitory effect on tyrosinase activity and reduced tyrosinase expression in the melan-a cells. Moreover, cinnamic acid exhibited depigmenting activity on the UV-B-induced hyperpigmentation of brown guinea pig skin. Our results suggest that cinnamic acid might act as a skin whitening agent via inhibition of tyrosinase activity and expression within melanocytes.
Yeon Hee Kong; Youn Ock Jo; Chang-Won Cho; Dongwook Son; Soojin Park; Jeonghae Rho; Sang Yoon Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  31     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  946-8     Citation Subset:  IM    
Korea Food Research Institute, Songnam 463-746, Korea.
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MeSH Terms
Antioxidants / pharmacology
Blotting, Western
Cell Survival
Cinnamates / pharmacology*
Guinea Pigs
Hyperpigmentation / prevention & control
Intramolecular Oxidoreductases / metabolism
Melanins / antagonists & inhibitors*,  biosynthesis*
Monophenol Monooxygenase / antagonists & inhibitors
Pyrones / pharmacology
Radiation-Protective Agents / pharmacology
Skin / drug effects*,  metabolism*
Spectrophotometry, Ultraviolet
Ultraviolet Rays
Reg. No./Substance:
0/Antioxidants; 0/Cinnamates; 0/Melanins; 0/Pyrones; 0/Radiation-Protective Agents; 501-30-4/kojic acid; 621-82-9/cinnamic acid; EC Monooxygenase; EC 5.3.-/Intramolecular Oxidoreductases; EC isomerase

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