Document Detail

Inhibitory effects of bovine lactoferrin and lactoferricin B on Enterobacter sakazakii.
MedLine Citation:
PMID:  18432114     Owner:  NLM     Status:  MEDLINE    
The susceptibility of Enterobacter sakazakii, a food-borne pathogen, to several metal-bound forms of bovine lactoferrin (LF), pepsin-hydrolyzed LF (LF-hyd), and LF-derived peptide lactoferricin B (LFcin B) was tested. MIC and MBC testing revealed that 4 strains of E. sakazakii show susceptibility to apo- and Cu-LF, LF-hyd, and LFcin B, but not to Fe-LF, similarly to Escherichia coli. A growth curve test indicated that E. sakazakii was inhibited in a dose-dependent manner by apo-LF at 0.5 to 8 mg/ml. Even after being heated at 80 degrees C, LF at above 1 mg/ml inhibited the bacterial growth. These results suggest that bovine LF-related compounds may be useful for the inhibition of E. sakazakii in foods.
Hiroyuki Wakabayashi; Koji Yamauchi; Mitsunori Takase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biocontrol science     Volume:  13     ISSN:  1342-4815     ISO Abbreviation:  Biocontrol Sci     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-24     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712121     Medline TA:  Biocontrol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 228-8583, Japan.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Enterobacter sakazakii / drug effects*,  growth & development
Lactoferrin / pharmacology*
Microbial Sensitivity Tests
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lactoferrin; 146897-68-9/lactoferricin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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