Document Detail

Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages.
MedLine Citation:
PMID:  21771629     Owner:  NLM     Status:  Publisher    
Although (-)-α-bisabolol, a natural monocyclic sesquiterpene alcohol, is often used as a cosmetic soothing supplement, little is known about its mechanisms of anti-inflammatory effects. Therefore, this study was designed to investigate anti-inflammatory effects of (-)-α-bisabolol and its mechanisms of action. In this study, we found that (-)-α-bisabolol inhibited lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E2 (PGE(2)) in RAW264.7 cells. In addition, expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) genes was reduced, as evidenced by Western blot and luciferase reporter assays for COX-2 and iNOS. To assess the mechanism of the anti-inflammatory property of (-)-α-bisabolol, its effects on the activity of AP-1 and NF-κB promoters were examined. LPS-induced activation of AP-1 and NF-κB promoters was significantly reduced by (-)-α-bisabolol. Consistently, (-)-α-bisabolol reduced LPS-induced phosphorylation of IκBα. In addition, while LPS-induced phosphorylation of ERK and p38 was attenuated by (-)-α-bisabolol, significant changes in the level of phosphorylated JNK were not observed. Our results indicate that (-)-α-bisabolol exerts anti-inflammatory effects by downregulating expression of iNOS and COX-2 genes through inhibition of NF-κB and AP-1 (ERK and p38) signaling.
Seungbeom Kim; Eunsun Jung; Jang-Hyun Kim; Young-Ho Park; Jongsung Lee; Deokhoon Park
Related Documents :
1465399 - Human t-cell leukemia virus type i infection of monocytes and microglial cells in prima...
12010569 - Tissue factor as a proinflammatory agent.
1696299 - Angiogenic activity is defective in monocytes from patients with alopecia universalis.
21586819 - A novel combination of trail and doxorubicin enhances antitumor effect based on passive...
21086009 - The effect of a single episode of antimicrobial photodynamic therapy in the treatment o...
20933269 - Macrophage differentiation and polarization on a decellularized pericardial biomaterial.
22394219 - Ubiquitination-mediated regulation of interferon responses.
15351849 - Compartment- and cell-specific expression of coagulation and fibrinolysis factors in th...
23913419 - The virulence of salmonella enterica serovar typhimurium in the insect model galleria m...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-13
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, 462-807 Gyunggi Do, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice.
Next Document:  Effects of repeated maternal oral exposure to low levels of trichlorfon on development and cytogenet...