Document Detail


Inhibitory effects on bacterial growth and beta-ketoacyl-ACP reductase by different species of maple leaf extracts and tannic acid.
MedLine Citation:
PMID:  19444866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is important to develop new antibiotics aimed at novel targets. The investigation found that the leaf extracts from five maples (Acer platanoides, Acer campestre, Acer rubrum, Acer saccharum and Acer truncatum Bunge collected in Denmark, Canada and China) and their component tannic acid displayed antibacterial ability against 24 standard bacteria strains with the minimum inhibitory concentration of 0.3-8.0 mg/mL. Unlike the standard antibiotic levofloxacin (LFX), these samples inhibited Gram-positive bacteria more effectively than they inhibited Gram-negative bacteria. These samples effectively inhibited two antidrug bacterial strains. The results show that these samples inhibit bacteria by a different mechanism from LFX. These samples potently inhibited b-ketoacyl-ACP reductase (FabG), which is an important enzyme in bacterial fatty acid synthesis. Tannic acid showed the strongest inhibition on FabG with a half inhibition concentration of 0.78 microM (0.81 microg/mL). Furthermore, tannic acid and two maple leaf extracts showed time-dependent irreversible inhibition of FabG. These three samples also exhibited better inhibition on bacteria. It is suggested that FabG is the antibacteria target of maple leaf extracts and tannic acid, and both reversible and irreversible inhibitions of FabG are important for the antibacterial effect.
Authors:
Dan Wu; Xiao-Dong Wu; Xue-Fu You; Xiao-Feng Ma; Wei-Xi Tian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24 Suppl 1     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-05-10     Revised Date:  2010-05-12    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  S35-41     Citation Subset:  IM    
Affiliation:
College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing, P. R. China.
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MeSH Terms
Descriptor/Qualifier:
Acer / chemistry*
Alcohol Oxidoreductases / drug effects*,  metabolism
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects*,  enzymology,  growth & development
Bacterial Proteins / drug effects,  metabolism
Fatty Acids / biosynthesis
Microbial Sensitivity Tests
Ofloxacin / pharmacology
Plant Extracts / pharmacology*
Plant Leaves / chemistry
Tannins / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/Fatty Acids; 0/Plant Extracts; 0/Tannins; 82419-36-1/Ofloxacin; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.100/3-oxoacyl-(acyl-carrier-protein) reductase
Comments/Corrections
Erratum In:
Phytother Res. 2010 Apr;24(4):632

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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