Document Detail


Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity.
MedLine Citation:
PMID:  1756516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Topical application of 100 mg/kg body weight of Ixora javanica flower extract inhibited the growth and delayed the onset of papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA) and promoted using croton oil. The extract at the same dose, when administered orally inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA)-induced soft tissue fibrosarcomas significantly. Oral administration of 200 mg/kg of the extract inhibited the growth of intraperitoneally transplanted sarcoma-180 and Ehrlich ascites carcinoma tumours besides showing an increase in the life span of the treated mice. Toxicity studies showed that the blood urea nitrogen levels were elevated post treatment. The active compounds responsible for the above inhibitory effects on tumour growth were identified as ferulic acid (4-hydroxy-3-methoxy cinnamic acid) and its regionmer 3-hydroxy-4-methoxy cinnamic acid.
Authors:
S C Nair; B Panikkar; K G Akamanchi; K R Panikkar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  60     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-03     Completed Date:  1992-02-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Affiliation:
Amala Cancer Research Centre, Kerala, India.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene
Administration, Oral
Animals
Antineoplastic Agents, Phytogenic / therapeutic use*
Carcinoma, Ehrlich Tumor / drug therapy*
Croton Oil
Male
Methylcholanthrene
Mice
Mice, Inbred Strains
Papilloma / chemically induced,  pathology,  prevention & control*
Plant Extracts / therapeutic use*
Sarcoma 180 / drug therapy*
Sarcoma, Experimental / chemically induced,  pathology,  prevention & control*
Skin Neoplasms / chemically induced,  pathology,  prevention & control*
Soft Tissue Neoplasms / chemically induced,  pathology,  prevention & control*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 56-49-5/Methylcholanthrene; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 8001-28-3/Croton Oil

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