| Inhibitory effects of Ginsenoside Rb1 on apoptosis caused by HSV-1 in Human Glioma Cells. | |
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MedLine Citation:
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PMID: 22270803 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To investigate the inhibitory effects of Ginsenoside Rb1 (GRb1) on apoptosis caused by Herpes Simplex Virus-1(HSV-1) in Human Glioma Cells (U251), U251 cells were infected by HSV-1 at a multiplicity of infection of 5 and GRb1, GRb1+HSV-1, HSV-1 and control groups. MTT and cell apoptosis assays were used to detect the inhibitory effects of GRb1 on the apoptosis of U251 cells that caused by HSV-1 infection for various concentrations of drug and virus treatments by MTT assay. We found that in the 400 μg/mL GRb1 and 400 μg/mL GRb1+HSV-1 groups, MTT values were higher than control group at all times (P<0. 05). Moreover, the apoptosis rate in the 400 μg/mL GRb1+HSV-1 group was lower than the HSV-1 group (P<0. 05). These results confirmed that, at appropriate concentrations, GRb1 could inhibit nerve cell apoptosis in HSV-1 infections. |
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Authors:
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Yuan-Yuan Liang; Bin Wang; Dong-Meng Qian; Ling Li; Zhi-Hao Wang; Ming Hu; Xu-Xia Song |
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Publication Detail:
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Type: Journal Article Date: 2012-01-22 |
Journal Detail:
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Title: Virologica Sinica Volume: 27 ISSN: 1995-820X ISO Abbreviation: Virol Sin Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101514185 Medline TA: Virol Sin Country: China |
Other Details:
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Languages: eng Pagination: 19-25 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Key Laboratory of Medicine and Biotechnology of Qingdao, Qingdao University, Qingdao, 266071, Shandong, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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