Document Detail

Inhibitory effect of selenite on invasion of HT1080 tumor cells.
MedLine Citation:
PMID:  11274215     Owner:  NLM     Status:  MEDLINE    
Selenium, an essential biological trace element, has been shown to reduce and prevent the incidence of cancer. Our previous studies have shown that selenite is involved in the chemoprevention of cancer and induction of apoptosis of cancer cells. In this study, we demonstrate that selenite also inhibits the invasion of tumor cells. Cancer cell invasion requires coordinated processes, such as changes in cell-cell and cell-matrix adhesion, degradation of the extracellular matrix, and cell migration. We found that selenite inhibited invasion of HT1080 human fibrosarcoma cells. Adhesion of HT1080 cells to the collagen matrix was also inhibited by treatment with selenite, but cell-cell interaction and cell motility were not affected by selenite. Moreover, selenite reduced expression of matrix metalloproteinase-2 and -9 and urokinase-type plasminogen activator, which are involved in matrix degradation, but increased a tissue inhibitor of metalloproteinase-1. This inhibitory effect of selenite on the protease expressions was mediated by the suppression of transcription factors, NF-kappaB and AP-1. However, selenate showed no remarkable effect on all the steps of cancer cell invasion.
S O Yoon; M M Kim; A S Chung
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Publication Detail:
Type:  Journal Article     Date:  2001-03-27
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  276     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-04     Completed Date:  2001-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20085-92     Citation Subset:  IM    
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305-701, South Korea.
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MeSH Terms
Cell Adhesion
Cell Division / drug effects
Extracellular Matrix Proteins / metabolism
Neoplasm Invasiveness / prevention & control*
Neoplasm Metastasis / prevention & control
Selenium Compounds / pharmacology
Sodium Selenite / pharmacology*
Tissue Inhibitor of Metalloproteinase-1 / genetics
Transcription, Genetic / drug effects
Tumor Cells, Cultured
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Selenium Compounds; 0/Tissue Inhibitor of Metalloproteinase-1; 10102-18-8/Sodium Selenite; 7783-08-6/selenic acid

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