Document Detail

Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats.
MedLine Citation:
PMID:  11432450     Owner:  NLM     Status:  MEDLINE    
The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats were given oral intubation of resveratrol (5 mg/day/100 g body weight) for 14 days, while control nephritic rats as well as normal ones were similarly given vehicle alone. By resveratrol treatment, enlargement in liver and kidney due to nephritis induction was significantly reduced, together with partial restoration of nephritis-induced reduction in body weight gain. Both proteinuria and hypoalbuminemia, characteristic symptoms to nephrotic syndrome, were significantly remedied, that is, urinary protein excretion was suppressed and serum albumin concentration was increased by resveratrol treatment. Resveratrol also suppressed significantly hyperlipidemia incident to nephritis, the hypotriglyceridemic action being more prominent than the hypocholesterolemic one. From these results, resveratrol is suggested to be a potent anti-glomerulonephritic food factor capable of suppressing proteinuria, hypoalbuminemia and hyperlipidemia at the same time.
T Nihei; Y Miura; K Yagasaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  68     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-02     Completed Date:  2001-07-12     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2845-52     Citation Subset:  IM    
Department of Applied Biological Science, Tokyo Noko University, Fuchu, Japan.
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MeSH Terms
Administration, Oral
Albumins / analysis,  deficiency
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  therapeutic use*
Basement Membrane / immunology
Blood Urea Nitrogen
Body Weight / drug effects
Cholesterol / blood
Disease Models, Animal
Eating / drug effects
Glomerulonephritis / complications,  drug therapy*,  immunology
Hyperlipidemias / drug therapy*,  etiology
Hypoproteinemia / drug therapy*,  etiology
Kidney / drug effects,  pathology
Kidney Glomerulus / immunology,  pathology
Liver / drug effects,  metabolism,  pathology
Organ Size / drug effects
Proteinuria / drug therapy*,  etiology
Rats, Wistar
Stilbenes / administration & dosage,  therapeutic use*
Triglycerides / blood
Reg. No./Substance:
0/Albumins; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Stilbenes; 0/Triglycerides; 57-88-5/Cholesterol; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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