| Inhibitory effect of platinum and ruthenium bipyridyl complexes on porcine pancreatic phospholipase A(2). | |
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MedLine Citation:
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PMID: 21909579 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pancreatic phospholipase A(2) (PLA(2)) plays an important role in cellular homeostasis as well as in the process of carcinogenesis. Effects of metallo-drugs used as chemotherapeutics on the activity of this enzyme are unknown. In this work, the interaction between porcine pancreatic PLA(2) and two selected transition metal complexes-tetrachloro(bipyridine) platinum(iv) ([PtCl(4)(bipy)]) and dichloro (bipyridine) ruthenium(iii)chloride ([RuCl(2)(bipy)(2)]Cl)-was studied. Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) and fluorescence spectroscopy have been used to analyse the enzyme activity in the absence and presence of metal complexes and to verify potential binding of these drugs to the enzyme. The tested metal complexes decreased the activity of phospholipase A(2) in an uncompetitive inhibition mode. A binding of the ruthenium complex near the active site of the enzyme could be evidenced and possible modes of interaction are discussed. |
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Authors:
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Tina Kamčeva; Jörg Flemmig; Bojana Damnjanović; Jürgen Arnhold; Aleksandar Mijatović; Marijana Petković |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-12 |
Journal Detail:
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Title: Metallomics : integrated biometal science Volume: - ISSN: 1756-591X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101478346 Medline TA: Metallomics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Physical Chemistry, Institute of Nuclear Sciences "Vinča", University of Belgrade, Mike Petrovića Alasa 12-14, Belgrade, Serbia. tina@vinca.rs, marijanapetkovic@vinca.rs, bojanad@vinca.rs. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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