Document Detail


Inhibitory effect of l-ascorbic acid on the growth of astrocytes in cell culture.
MedLine Citation:
PMID:  3205384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of l-ascorbic acid on the growth of astrocytic cells in culture was investigated. l-Ascorbic acid produced a concentration-dependent reduction of the growth of astrocytes, both in normal and tumor cells. The effect of l-ascorbic acid was similar to that of the relative acidification of the medium, except in treated concentrations greater than 10(-6) M. The effects produced by both l- and d-forms of ascorbic acid were the same. The inhibitory effect of l-ascorbic acid at greater concentrations was partially prevented by oxidized glutathione and increased by the large concentration of reduced glutathione. This result suggests that l-ascorbic acid possesses the ability to inhibit the growth of astrocytic cells in culture through the acidification of the medium at small concentrations and/or the antioxidative properties of this compound at larger concentrations.
Authors:
J T Cheng; C F Yang; T C Jou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropharmacology     Volume:  27     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1179-82     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Ascorbic Acid / pharmacology*
Astrocytes / drug effects*
Cell Count
Cells, Cultured
Glutathione / pharmacology
Rats
Stereoisomerism
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
50-81-7/Ascorbic Acid; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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