Document Detail

Inhibitory effect of curcumin on uterine leiomyoma cell proliferation.
MedLine Citation:
PMID:  20672906     Owner:  NLM     Status:  In-Data-Review    
Objective. Uterine leiomyomas are the most common gynaecological benign tumour and greatly affect reproductive health and wellbeing. They are the predominant indication for hysterectomy in premenopausal women. Curcumin, a well-known component of turmeric, has been reported to prevent various diseases such as cancer, diabetes and obesity. Previous study reported that curcumin represses the proliferation of several tumour cells. However, there has not been a precise characterisation of the curcumin-induced inhibition of uterine leiomyoma cells. In this study, we investigated the inhibitory effect of curcumin on leiomyoma cells proliferation. Study design. Eker rat-derived uterine leiomyoma cell lines (ELT-3 cells) were used. Cell proliferation was assessed by counting the number of cells and MTS assay. The activation of peroxisome proliferator-activated receptor-gamma (PPARγ) was evaluated by luciferase assay. Results. We found that curcumin significantly inhibited ELT-3 cell proliferation. PPARγ was expressed in ELT-3 cells and curcumin acted as a PPARγ ligand. This inhibitory effect of curcumin was attenuated by the treatment of cells with PPARγ antagonist. Conclusion. These experimental findings in vitro show that the inhibitory effect of curcumin on ELT-3 cell proliferation occurs through the activation of PPARγ. Curcumin may be useful as an alternative therapy for uterine leiomyoma.
Kenji Tsuiji; Takashi Takeda; Bin Li; Atsuko Wakabayashi; Akiko Kondo; Tadashi Kimura; Nobuo Yaegashi
Related Documents :
21043356 - Granular cell myoblastoma of the tongue in a 2-year-old girl: a case report.
19192636 - Alpha-bisabolol: unexpected plant-derived weapon in the struggle against tumour survival?
6314486 - Gut peptide production by tumour cell lines in culture.
10633826 - Tumour metastasis to the liver, and the roles of proteinases and adhesion molecules: ne...
14555536 - Retinoid receptor-dependent and independent biological activities of novel fenretinide ...
23399596 - Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming.
Publication Detail:
Type:  Journal Article     Date:  2010-07-30
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  27     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
Center for Asian Traditional Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pheochromocytoma and medullary thyroid carcinoma in a pregnant multiple endocrine neoplasia-2A patie...
Next Document:  Why kisspeptin is such important for reproduction?