| Inhibitory effect of cinnamoyl compounds against human malignant cell line. | |
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MedLine Citation:
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PMID: 16538860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (CMN), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. CMN inhibited the proliferation of K562 leukemic cells by induction of apoptosis. The current study demonstrated synergy with combination of drug therapy, and suggested that combination of ferulic acid and cisplatin synergistically inhibited cellular proliferation. Cytotoxic synergy was observed independent of the sequence of addition of two drugs to cultured cells. The synergized growth inhibitory effect with cisplatin was probably associated with G2-M arrest in cell cycle progression. These findings suggested that among the cinnamoyl compounds, CMN was most potent and FER appeared to be a better modulating agent on human malignant cell line. |
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Authors:
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M A Indap; S Radhika; Leena Motiwale; K V K Rao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 44 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 216-20 Citation Subset: IM |
Affiliation:
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Chemotherapy Group, Khanolkar Shodhika, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemistry*,
pharmacology* Cell Cycle / drug effects* Cell Proliferation / drug effects Cisplatin / chemistry, pharmacology Curcuma / chemistry* Curcumin / chemistry*, pharmacology* Cyclodextrins / chemistry, pharmacology Flavonoids / chemistry, pharmacology Humans K562 Cells Leukemia, Erythroblastic, Acute / pathology* Phenols / chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cyclodextrins; 0/Flavonoids; 0/Phenols; 0/polyphenols; 15663-27-1/Cisplatin; 458-37-7/Curcumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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