Document Detail


Inhibitory effect of chicken gonadotropin-releasing hormone II on food intake in the goldfish, Carassius auratus.
MedLine Citation:
PMID:  18342861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gonadotropin-releasing hormone (GnRH) is an evolutionarily conserved neuropeptide with 10 amino acid residues, which possesses some structural variants. A molecular form known as chicken GnRH II ([His(5) Trp(7) Tyr(8)] GnRH, cGnRH II) is widely distributed in vertebrates, and has recently been implicated in the regulation of sexual behavior and food intake in an insectivore, the musk shrew. However, the influence of cGnRH II on feeding behavior has not yet been studied in model animals such as rodents and teleost fish. In this study, therefore, we investigated the role of cGnRH II in the regulation of feeding behavior in the goldfish, and examined its involvement in food intake after intracerebroventricular (ICV) administration. ICV-injected cGnRH II at graded doses, from 0.1 to 10 pmol/g body weight (BW), induced a decrease of food consumption in a dose-dependent manner during 60 min after treatment. Cumulative food intake was significantly decreased by ICV injection of cGnRH II at doses of 1 and 10 pmol/g BW during the 60-min post-treatment observation period. ICV injection of salmon GnRH ([Trp(7) Leu(8)] GnRH, sGnRH) at doses of 0.1-10 pmol/g BW did not affect food intake. The anorexigenic action of cGnRH II was completely blocked by treatment with the GnRH type I receptor antagonist, Antide. However, the anorexigenic action of cGnRH II was not inhibited by treatment with the corticotropin-releasing hormone (CRH) 1/2 receptor antagonist, *-helical CRH((9-41)), and the melanocortin 4 receptor antagonist, HS024. These results suggest that, in the goldfish, cGnRH II, but not sGnRH, acts as an anorexigenic factor, as is the case in the musk shrew, and that the anorexigenic action of cGnRH II is independent of CRH- and melanocortin-signaling pathways.
Authors:
Kouhei Matsuda; Kouta Nakamura; Sei-Ichi Shimakura; Tohru Miura; Haruaki Kageyama; Minoru Uchiyama; Seiji Shioda; Hironori Ando
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-13
Journal Detail:
Title:  Hormones and behavior     Volume:  54     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-27     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Affiliation:
Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan. kmatsuda@sci.u-toyama.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / chemically induced
Chickens
Corticotropin-Releasing Hormone / antagonists & inhibitors,  pharmacology
Eating / drug effects*,  physiology
Female
Goldfish / physiology*
Gonadotropin-Releasing Hormone / administration & dosage,  analogs & derivatives*,  pharmacology
Hormone Antagonists / pharmacology
Injections, Intraventricular
Male
Oligopeptides / pharmacology
Peptide Fragments / pharmacology
Peptides, Cyclic / pharmacology
Receptors, Corticotropin / antagonists & inhibitors
Sex Characteristics
Chemical
Reg. No./Substance:
0/HS 024; 0/Hormone Antagonists; 0/Oligopeptides; 0/Peptide Fragments; 0/Peptides, Cyclic; 0/Receptors, Corticotropin; 112568-12-4/iturelix; 33515-09-2/Gonadotropin-Releasing Hormone; 9015-71-8/Corticotropin-Releasing Hormone; 91097-16-4/LHRH, His(5)-Trp(7)-Tyr(8)-; 96118-75-1/corticotropin releasing hormone (9-41)

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