| Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells. | |
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MedLine Citation:
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PMID: 8973597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caffeic acid phenethyl ester (CAPE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAPE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 microM, 5.0 microM and 1.5 microM, respectively. |
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Authors:
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J H Chen; Y Shao; M T Huang; C K Chin; C T Ho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 108 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-09 Completed Date: 1997-01-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 211-4 Citation Subset: IM |
Affiliation:
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Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers, State University of New Jersey, New Brunswick 08903, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents
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pharmacology* Caffeic Acids / pharmacology* Drug Screening Assays, Antitumor HL-60 Cells Humans Phenylethyl Alcohol / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Caffeic Acids; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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