| Inhibitory effect of Lactobacillus gasseri TMC0356 and Lactobacillus GG on enhanced vascular permeability of nasal mucosa in experimental allergic rhinitis of rats. | |
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MedLine Citation:
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PMID: 17151443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nasal vascular permeability of ovablumin (OVA)-sensitized Brown Norway rats was evaluated by analyzing a brilliant blue concentration in perfusate from the nose after exposure of the nasal mucus to OVA. Oral administration of Lactobacillus GG and L. gasseri TMC0356 significantly inhibited the increase in nasal vascular permeability (P<0.01). The serum IgE of the tested rats also decreased, although the change was not statistically significant. These results indicate that Lactobacillus GG and L. gasseri TMC0356 might alleviate nasal allergic symptoms by suppressing the increase in nasal vascular permeability caused by local inflammation associated with allergic rhnititis. |
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Authors:
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Manabu Kawase; Fang He; Akira Kubota; Jun-Ya Hata; Shin-Ichiro Kobayakawa; Masaru Hiramatsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 70 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 3025-30 Citation Subset: IM |
Affiliation:
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Technical Research Laboratory, Takanashi Milk Products Co., Ltd., Yokohama. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Permeability* Lactobacillus* Male Nasal Mucosa / blood supply* Rats Rhinitis, Allergic, Perennial / therapy* |
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