Document Detail


Inhibitory effect of 2"-O-glycosyl isovitexin and alpha-tocopherol on genotoxic glyoxal formation in a lipid peroxidation system.
MedLine Citation:
PMID:  7959459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of 2"-O-glycosyl isovitexin (2"-O-GIV), isolated from young barley leaves, on glyoxal formation from the oxidative degradation of three fatty acid ethyl esters was measured. Ethyl linoleate, ethyl linolenate and ethyl arachidonate were oxidized by Fenton's reagent. Glyoxal formed from these fatty acid esters was analysed by gas chromatography after it had been derivatized to quinoxaline with 1,2-phenylenediamine. The comparative study was performed using alpha-tocopherol. Generally, alpha-tocopherol exhibited a greater inhibitory effect at lower levels, whereas 2"-O-GIV showed a greater effect than alpha-tocopherol at higher levels. 2"-O-GIV was more effective than alpha-tocopherol towards fatty acid esters with high numbers of double bonds. 2"-O-GIV exhibited a dose-response effect but alpha-tocopherol did not. Maximum inhibition of 82% was obtained from oxidation of ethyl arachidonate at 8 mumol 2"-O-GIV, whereas maximum inhibition of 77% was observed from oxidation of ethyl arachidonate at 0.25 mumol alpha-tocopherol.
Authors:
T Nishiyama; Y Hagiwara; H Hagiwara; T Shibamoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  32     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-23     Completed Date:  1994-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1047-51     Citation Subset:  IM    
Affiliation:
Department of Environmental Toxicology, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / chemistry
Carbohydrate Sequence
Flavonoids / chemistry*,  isolation & purification
Glyoxal / analysis,  chemistry*
Hydrogen Peroxide
Iron
Isoflavones*
Linoleic Acids / chemistry
Linolenic Acids / chemistry
Lipid Peroxidation
Molecular Sequence Data
Oxidation-Reduction
Vitamin E / chemistry*
Chemical
Reg. No./Substance:
0/2''-O-glycosylisovitexin; 0/Arachidonic Acids; 0/Fenton's reagent; 0/Flavonoids; 0/Isoflavones; 0/Linoleic Acids; 0/Linolenic Acids; 107-22-2/Glyoxal; 1191-41-9/ethyl linolenate; 1406-18-4/Vitamin E; 1808-26-0/ethyl arachidonate; 544-35-4/ethyl linoleate; 7439-89-6/Iron; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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