| Inhibitory control at a synaptic relay. | |
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MedLine Citation:
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PMID: 15028756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mammalian medial nucleus of the trapezoid body (MNTB) harbors one of the most powerful terminals in the CNS, the calyx of Held. The mechanisms known to regulate this synaptic relay are relatively ineffective. Here, we report the presence of a remarkably robust and fast-acting glycinergic inhibitory system capable of suppressing calyceal transmission. Evoked glycinergic IPSCs were relatively small in 2-week-old rats, an age by which calyceal maturation has reportedly neared completion. However, by postnatal day 25 (P25), glycinergic transmission had undergone a vigorous transformation, resulting in peak synaptic conductances as high as 280 nS. These are comparable with glutamatergic conductances activated by calyceal inputs. Decay kinetics for IPSCs were severalfold faster than for glycinergic synaptic events reported previously. At physiological temperatures in P25 rats, IPSCs decayed in approximately 1 msec and could be elicited at frequencies up to 500 Hz. Moreover, EPSPs triggered by glutamatergic signals derived from the calyx or simulated by conductance clamp were suppressed when preceded by simulated glycinergic IPSPs. The matching of excitatory transmission in the calyx of Held by a powerful, precision inhibitory system suggests that the relay function of the MNTB may be rapidly modified during sound localization. |
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Authors:
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Gautam B Awatramani; Rostislav Turecek; Laurence O Trussell |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 24 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-18 Completed Date: 2004-05-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 2643-7 Citation Subset: IM |
Affiliation:
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Oregon Hearing Research Center/Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA. awatrama@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Auditory Pathways / physiology* Brain Stem / cytology, drug effects, physiology* Electric Stimulation / methods Excitatory Postsynaptic Potentials / drug effects, physiology GABA Antagonists / pharmacology Glutamic Acid / metabolism Glycine / metabolism Glycine Agents / pharmacology Neural Inhibition / drug effects, physiology* Neurons / drug effects, metabolism, physiology* Patch-Clamp Techniques Rats Sound Localization / physiology Synapses / physiology* Synaptic Transmission / drug effects, physiology Temperature |
| Grant Support | |
ID/Acronym/Agency:
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DC04450/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GABA Antagonists; 0/Glycine Agents; 56-40-6/Glycine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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