| Inhibitory circuits in human dysplastic tissue. | |
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MedLine Citation:
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PMID: 10999539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Different types of epilepsies and seizures depend on the nature and location of the primary disturbance and are presumably mediated by different physiopathological mechanisms. We immunocytochemically investigated possible changes in the inhibitory-aminobutyric acid (GABA)ergic system in specimens taken from four patients who underwent surgery for intractable epilepsy and presented two different types of focal cortical dysplasia in the temporal lobe. METHODS: The patients were selected on the basis of electroclinical, imaging, and routine neuropathological data: two had Taylor focal dysplasia, and two had non-Taylor dysplasia (microdysgenesia). The study was performed using antibodies against parvalbumin (PV), glutamic acid decarboxylase (GAD), and GABA-transporter 1 (GAT1). RESULTS: In the patients with Taylor dysplasia, laminar disorganization of the cortex was associated with the presence of giant neurons and ballooned cells; there was a reduced number of PV-positive neurons and terminals, the giant neurons were surrounded by clusters of PV- and GAD-positive terminals, and there was an overall reduction in GAT1. Despite the presence of cortical laminar disorganization, no giant or ballooned cells were found in the patients with non-Taylor microdysgenesia; there was a marked decrease in PV and GAD immunoreactive elements, with a patchy distribution of GAD and GAT1 immunoreactivity but no clustering of PV and GAD terminals. CONCLUSIONS: These results suggest that the two forms of cortical dysplasia are characterized by different and selective morphofunctional alterations in the GABAergic system. |
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Authors:
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R Spreafico; L Tassi; N Colombo; M Bramerio; C Galli; R Garbelli; A Ferrario; G Lo Russo; C Munari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 41 Suppl 6 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2000 |
Date Detail:
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Created Date: 2000-10-17 Completed Date: 2000-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S168-73 Citation Subset: IM |
Affiliation:
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Divisione di Neurofisiologia Sperimentale ed Epilettologia, Istituto Nazionale Neurologico C. Besta, Milan, Italy. spreafico@istituto-besta.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebral Cortex / abnormalities*, pathology*, physiopathology Epilepsy, Temporal Lobe / pathology*, physiopathology Female Humans Immunohistochemistry Magnetic Resonance Imaging Male Neural Inhibition / physiology* Neural Pathways / pathology* Neurons / pathology* Temporal Lobe / pathology*, physiopathology gamma-Aminobutyric Acid / physiology |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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