| Inhibitory avoidance task does not change NCS-1 level in rat brain. | |
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MedLine Citation:
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PMID: 20493243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Step-down inhibitory avoidance is usually acquired in one single trial, which makes it ideal for studying processes initiated by training, uncontaminated by prior or further trials, rehearsals, or retrievals. Neuronal calcium sensor 1 (NCS-1) is a dopamine receptor interacting protein that has been associated with associative learning and memory. We evaluated whether inhibitory avoidance can alter NCS-1 levels in rat brain. We focused our analysis on the striatum, entorhinal cortex, hippocampus and prefrontal cortex. Protein levels were measured using immunoblotting normalized by actin levels. Our results indicate that NCS-1 levels are not altered after step-down inhibitory avoidance in rat striatum, entorhinal cortex, hippocampus and prefrontal cortex. The link between protein interactions and the varied physiological roles of NCS-1 still remains to be fully established. Furthermore, other experiments are needed to shed more light on the role of NCS-1 and other mechanisms linked to signaling pathways related to inhibitory avoidance task. |
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Authors:
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Daniela V F Rosa; Renan P Souza; Bruno R Souza; Fabrício F Lima; Samira S Valvassori; Marcus V Gomez; João Quevedo; Marco A Romano-Silva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-20 |
Journal Detail:
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Title: Brain research bulletin Volume: 82 ISSN: 1873-2747 ISO Abbreviation: Brain Res. Bull. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
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Languages: eng Pagination: 289-92 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratório de Neurociência e Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Departamento de Saúde Mental, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av Alfredo Balena, 190 sl 114, Belo Horizonte 30130-100, MG, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avoidance Learning / physiology* Behavior, Animal Brain / anatomy & histology, metabolism* Electroshock / adverse effects Gene Expression Regulation / physiology* Inhibition (Psychology)* Male Memory / physiology* Neuronal Calcium-Sensor Proteins / metabolism* Neuropeptides / metabolism* Rats Rats, Wistar Statistics, Nonparametric Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Neuronal Calcium-Sensor Proteins; 0/Neuropeptides; 0/frequenin calcium sensor proteins |
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