Document Detail


Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilage fungi.
MedLine Citation:
PMID:  22517239     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to investigate the growth-inhibiting efficacy of Drosera intermedia extracts (water, methanol and n-hexane) against four food spoilage yeasts and five filamentous fungi strains responsible for food deterioration and associated with mycotoxin production, in order to identify potential antimycotic agents.
RESULTS: The n-hexane extract showed a broad activity spectrum against all tested microorganisms, followed, in activity, by the methanol and water extracts. The major component of the n-hexane extract was purified using a solid-phase extraction column and identified as plumbagin. Results show that high-purity plumbagin can be produced from D. intermedia cultures following a simple and effective isolation procedure. A sample of purified plumbagin was tested against the same panel of microorganisms and high growth-inhibiting capacity was observed. Minimum inhibitory concentrations less than 2 µg mL(-1) were obtained against the filamentous fungi. In the case of the species Aspergillus fumigatus, A. niger and A. flavus, activities comparable to miconazole were obtained.
CONCLUSION: The results obtained provided evidence of the antimycotic activity of plumbagin, suggesting that D. intermedia could be the source of an interesting compound for the food industry as an alternative to preservatives. Copyright © 2011 Society of Chemical Industry.
Authors:
Tomás Grevenstuk; Sandra Gonçalves; Telma Domingos; Célia Quintas; Justin Jj van der Hooft; Jacques Vervoort; Anabela Romano
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Publication Detail:
Type:  Journal Article     Date:  2011-12-20
Journal Detail:
Title:  Journal of the science of food and agriculture     Volume:  92     ISSN:  1097-0010     ISO Abbreviation:  J. Sci. Food Agric.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376334     Medline TA:  J Sci Food Agric     Country:  England    
Other Details:
Languages:  eng     Pagination:  1638-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Society of Chemical Industry.
Affiliation:
Centre of Genomics and Biotechnology, Faculty of Sciences and Technology, Institute for Biotechnology and Bioengineering, University of Algarve, 8005-139 Faro, Portugal.
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