Document Detail

Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase.
MedLine Citation:
PMID:  17690455     Owner:  NLM     Status:  MEDLINE    
Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC(50)=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC(50)=68 microM) and prostate cancer LNCaP cells (IC(50)=193 microM). Millet containing linoleic acid might have anti-tumor activity.
Nobuhiro Aburai; Yasuaki Esumi; Hiroyuki Koshino; Naoyuki Nishizawa; Ken-ichi Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  71     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-12-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2061-4     Citation Subset:  IM    
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka, Japan.
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MeSH Terms
Antineoplastic Agents / isolation & purification,  pharmacology
Cell Line, Tumor
Echinochloa / chemistry*
Enzyme Inhibitors / isolation & purification,  pharmacology,  therapeutic use
Histone Deacetylase Inhibitors*
Inhibitory Concentration 50
Leukemia / drug therapy,  pathology
Linoleic Acid / isolation & purification,  pharmacology*,  therapeutic use
Plant Extracts / chemistry
Prostatic Neoplasms / drug therapy,  pathology
Reg. No./Substance:
0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Plant Extracts; 2197-37-7/Linoleic Acid

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