Document Detail


Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase.
MedLine Citation:
PMID:  17690455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC(50)=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC(50)=68 microM) and prostate cancer LNCaP cells (IC(50)=193 microM). Millet containing linoleic acid might have anti-tumor activity.
Authors:
Nobuhiro Aburai; Yasuaki Esumi; Hiroyuki Koshino; Naoyuki Nishizawa; Ken-ichi Kimura
Related Documents :
8786265 - Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous ...
19630425 - Characterization and quantification of odor-active compounds in unsaturated fatty acid/...
7236215 - Stereospecific distribution of palmitic acid in the triacylglycerols of rat adipocytes....
8798265 - The very low birth weight premature infant is capable of synthesizing arachidonic and d...
7242275 - Effects of feeding chenodeoxycholic acid on metabolism of cholesterol and bile acids in...
3034525 - Kainic acid: insights into excitatory mechanisms causing selective neuronal degeneration.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  71     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-12-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2061-4     Citation Subset:  IM    
Affiliation:
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / isolation & purification,  pharmacology
Cell Line, Tumor
Echinochloa / chemistry*
Enzyme Inhibitors / isolation & purification,  pharmacology,  therapeutic use
Female
Histone Deacetylase Inhibitors*
Humans
Inhibitory Concentration 50
Leukemia / drug therapy,  pathology
Linoleic Acid / isolation & purification,  pharmacology*,  therapeutic use
Male
Plant Extracts / chemistry
Prostatic Neoplasms / drug therapy,  pathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Plant Extracts; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physicochemical properties of succinylated calfskin pepsin-solubilized collagen.
Next Document:  Assessment of prion inactivation by fenton reaction using protein misfolding cyclic amplification an...